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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Patel SJ, et al. Sci Transl Med. 2022 Mar 23;14(637):eabh3831. doi: 10.1126/scitranslmed.abh3831. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320000 Free PMC article.
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability.
Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW, Deshpande V, Singh G, Turner JR, Yarmush ML, Chung RT, Patel SJ. Luther J, et al. Among authors: patel sj. Cell Mol Gastroenterol Hepatol. 2015 Mar;1(2):222-232. doi: 10.1016/j.jcmgh.2015.01.001. Cell Mol Gastroenterol Hepatol. 2015. PMID: 26405687 Free PMC article.
Hepatic connexin 32 associates with nonalcoholic fatty liver disease severity.
Luther J, Gala MK, Borren N, Masia R, Goodman RP, Moeller IH, DiGiacomo E, Ehrlich A, Warren A, Yarmush ML, Ananthakrishnan A, Corey K, Kaplan LM, Bhatia S, Chung RT, Patel SJ. Luther J, et al. Among authors: patel sj. Hepatol Commun. 2018 Jul 16;2(7):786-797. doi: 10.1002/hep4.1179. eCollection 2018 Jul. Hepatol Commun. 2018. PMID: 30202815 Free PMC article.
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.
Luther J, Khan S, Gala MK, Kedrin D, Sridharan G, Goodman RP, Garber JJ, Masia R, Diagacomo E, Adams D, King KR, Piaker S, Reinecker HC, Yarmush ML, Argemi J, Bataller R, Dienstag JL, Chung RT, Patel SJ. Luther J, et al. Among authors: patel sj. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11667-11673. doi: 10.1073/pnas.1911870117. Epub 2020 May 11. Proc Natl Acad Sci U S A. 2020. PMID: 32393626 Free PMC article.
438 results