Patel MK - Search Results

1

Recent advances in the medicinal chemistry of sodium channel blockers and their therapeutic potential.

Zuliani V, Patel MK, Fantini M, Rivara M. Zuliani V, et al. Among authors: patel mk. Curr Top Med Chem. 2009;9(4):396-415. doi: 10.2174/156802609788317856. Curr Top Med Chem. 2009. PMID: 19442209 Review.

2

2,4(5)-Diarylimidazoles: synthesis and biological evaluation of a new class of sodium channel blockers against hNa(v)1.2.

Rivara M, Baheti AR, Fantini M, Cocconcelli G, Ghiron C, Kalmar CL, Singh N, Merrick EC, Patel MK, Zuliani V. Rivara M, et al. Among authors: patel mk. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5460-2. doi: 10.1016/j.bmcl.2008.09.036. Epub 2008 Sep 11. Bioorg Med Chem Lett. 2008. PMID: 18818069

3

2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.

Fantini M, Rivara M, Zuliani V, Kalmar CL, Vacondio F, Silva C, Baheti AR, Singh N, Merrick EC, Katari RS, Cocconcelli G, Ghiron C, Patel MK. Fantini M, et al. Among authors: patel mk. Bioorg Med Chem. 2009 May 15;17(10):3642-8. doi: 10.1016/j.bmc.2009.03.067. Epub 2009 Apr 10. Bioorg Med Chem. 2009. PMID: 19394229

4

Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models.

Zuliani V, Fantini M, Nigam A, Stables JP, Patel MK, Rivara M. Zuliani V, et al. Among authors: patel mk. Bioorg Med Chem. 2010 Nov 15;18(22):7957-65. doi: 10.1016/j.bmc.2010.09.029. Epub 2010 Sep 22. Bioorg Med Chem. 2010. PMID: 20943396 Free PMC article.

5

Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry.

Rivara M, Patel MK, Amori L, Zuliani V. Rivara M, et al. Among authors: patel mk. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6401-4. doi: 10.1016/j.bmcl.2012.08.067. Epub 2012 Aug 23. Bioorg Med Chem Lett. 2012. PMID: 22981330 Free PMC article.

6

Sodium channel blockers: a patent review (2010 - 2014).

Zuliani V, Rapalli A, Patel MK, Rivara M. Zuliani V, et al. Among authors: patel mk. Expert Opin Ther Pat. 2015 Mar;25(3):279-90. doi: 10.1517/13543776.2014.995628. Epub 2014 Dec 24. Expert Opin Ther Pat. 2015. PMID: 25539043 Review.

7

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.

Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, Doyle R, Printzenhoff D, Lin Z, Marron BE, West C, Swain NA, Storer RI, Stupple PA, Castle NA, Hounshell JA, Rivara M, Randall A, Dib-Hajj SD, Krafte D, Waxman SG, Patel MK, Butt RP, Stevens EB. Alexandrou AJ, et al. Among authors: patel mk. PLoS One. 2016 Apr 6;11(4):e0152405. doi: 10.1371/journal.pone.0152405. eCollection 2016. PLoS One. 2016. PMID: 27050761 Free PMC article.

8

Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2.

Hudgens DP, Taylor C, Batts TW, Patel MK, Brown ML. Hudgens DP, et al. Among authors: patel mk. Bioorg Med Chem. 2006 Dec 15;14(24):8366-78. doi: 10.1016/j.bmc.2006.09.010. Epub 2006 Oct 10. Bioorg Med Chem. 2006. PMID: 17035036 Free PMC article.

9

Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers.

De Oliveira EO, Graf KM, Patel MK, Baheti A, Kong HS, MacArthur LH, Dakshanamurthy S, Wang K, Brown ML, Paige M. De Oliveira EO, et al. Among authors: patel mk. Bioorg Med Chem. 2011 Jul 15;19(14):4322-9. doi: 10.1016/j.bmc.2011.05.043. Epub 2011 May 30. Bioorg Med Chem. 2011. PMID: 21683602 Free PMC article.

10

Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore.

Wang Y, Jones PJ, Batts TW, Landry V, Patel MK, Brown ML. Wang Y, et al. Among authors: patel mk. Bioorg Med Chem. 2009 Oct 1;17(19):7064-72. doi: 10.1016/j.bmc.2008.10.031. Epub 2008 Oct 17. Bioorg Med Chem. 2009. PMID: 19346132 Free PMC article.

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