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Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1.
March-Diaz R, Lara-Ureña N, Romero-Molina C, Heras-Garvin A, Ortega-de San Luis C, Alvarez-Vergara MI, Sanchez-Garcia MA, Sanchez-Mejias E, Davila JC, Rosales-Nieves AE, Forja C, Navarro V, Gomez-Arboledas A, Sanchez-Mico MV, Viehweger A, Gerpe A, Hodson EJ, Vizuete M, Bishop T, Serrano-Pozo A, Lopez-Barneo J, Berra E, Gutierrez A, Vitorica J, Pascual A. March-Diaz R, et al. Among authors: pascual a. Nat Aging. 2021 Apr;1(4):385-399. doi: 10.1038/s43587-021-00054-2. Epub 2021 Apr 15. Nat Aging. 2021. PMID: 37117599
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels.
Alvarez-Vergara MI, Rosales-Nieves AE, March-Diaz R, Rodriguez-Perinan G, Lara-Ureña N, Ortega-de San Luis C, Sanchez-Garcia MA, Martin-Bornez M, Gómez-Gálvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena MA, Bullones-Bolanos AS, Davila JC, Gonzalez-Martinez R, Trillo-Contreras JL, Sanchez-Hidalgo AC, Del Toro R, Scholl FG, Herrera E, Trepel M, Körbelin J, Escudero LM, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A. Alvarez-Vergara MI, et al. Among authors: pascual a. Nat Commun. 2021 May 25;12(1):3098. doi: 10.1038/s41467-021-23337-z. Nat Commun. 2021. PMID: 34035282 Free PMC article.
Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia.
Romero-Ruiz A, Bautista L, Navarro V, Heras-Garvín A, March-Díaz R, Castellano A, Gómez-Díaz R, Castro MJ, Berra E, López-Barneo J, Pascual A. Romero-Ruiz A, et al. Among authors: pascual a. J Biol Chem. 2012 Mar 16;287(12):9651-8. doi: 10.1074/jbc.M111.299180. Epub 2012 Feb 3. J Biol Chem. 2012. PMID: 22308030 Free PMC article.
Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits.
Ortega-de San Luis C, Sanchez-Garcia MA, Nieto-Gonzalez JL, García-Junco-Clemente P, Montero-Sanchez A, Fernandez-Chacon R, Pascual A. Ortega-de San Luis C, et al. Among authors: pascual a. Aging Cell. 2018 Oct;17(5):e12821. doi: 10.1111/acel.12821. Epub 2018 Jul 30. Aging Cell. 2018. PMID: 30058223 Free PMC article.
Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate.
Villadiego J, García-Arriaza J, Ramírez-Lorca R, García-Swinburn R, Cabello-Rivera D, Rosales-Nieves AE, Álvarez-Vergara MI, Cala-Fernández F, García-Roldán E, López-Ogáyar JL, Zamora C, Astorgano D, Albericio G, Pérez P, Muñoz-Cabello AM, Pascual A, Esteban M, López-Barneo J, Toledo-Aral JJ. Villadiego J, et al. Among authors: pascual a. Nat Neurosci. 2023 Feb;26(2):226-238. doi: 10.1038/s41593-022-01242-y. Epub 2023 Jan 9. Nat Neurosci. 2023. PMID: 36624276
1,034 results