Parra-Guillen ZP - Search Results

1

Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia.

Henrich A, Joerger M, Kraff S, Jaehde U, Huisinga W, Kloft C, Parra-Guillen ZP. Henrich A, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):347-358. doi: 10.1124/jpet.117.240309. Epub 2017 Jun 9. J Pharmacol Exp Ther. 2017. PMID: 28600397

2

Pharmacokinetics and pharmacokinetic-pharmacodynamic relationships of monoclonal antibodies in children.

Edlund H, Melin J, Parra-Guillen ZP, Kloft C. Edlund H, et al. Clin Pharmacokinet. 2015 Jan;54(1):35-80. doi: 10.1007/s40262-014-0208-4. Clin Pharmacokinet. 2015. PMID: 25516414 Review.

3

Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach.

Saafan H, Foerster S, Parra-Guillen ZP, Hammer E, Michaelis M, Cinatl J Jr, Völker U, Fröhlich H, Kloft C, Ritter CA. Saafan H, et al. Eur J Pharm Sci. 2016 Oct 30;94:20-32. doi: 10.1016/j.ejps.2016.04.025. Epub 2016 Apr 23. Eur J Pharm Sci. 2016. PMID: 27112992

4

Making use of modeling and simulations: Towards individualized tamoxifen therapy in breast cancer .

Klopp-Schulze L, Joerger M, Wicha SG, Parra-Guillen ZP, Kloft C. Klopp-Schulze L, et al. Int J Clin Pharmacol Ther. 2017 Aug;55(8):690-691. doi: 10.5414/CPXCES15EA05. Int J Clin Pharmacol Ther. 2017. PMID: 27641215 No abstract available.

5

Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.

Parra-Guillen ZP, Berger PB, Haschke M, Donzelli M, Winogradova D, Pfister B, Früh M, Gillessen S, Krähenbühl S, Kloft C, Joerger M. Parra-Guillen ZP, et al. Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):309-315. doi: 10.1111/bcpt.12801. Epub 2017 Jun 19. Basic Clin Pharmacol Toxicol. 2017. PMID: 28444958 Free article. Clinical Trial.

6

Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients.

Klopp-Schulze L, Joerger M, Wicha SG, Ter Heine R, Csajka C, Parra-Guillen ZP, Kloft C. Klopp-Schulze L, et al. Clin Pharmacokinet. 2018 Feb;57(2):229-242. doi: 10.1007/s40262-017-0555-z. Clin Pharmacokinet. 2018. PMID: 28540639

7

Model Description Language (MDL): A Standard for Modeling and Simulation.

Smith MK, Moodie SL, Bizzotto R, Blaudez E, Borella E, Carrara L, Chan P, Chenel M, Comets E, Gieschke R, Harling K, Harnisch L, Hartung N, Hooker AC, Karlsson MO, Kaye R, Kloft C, Kokash N, Lavielle M, Lestini G, Magni P, Mari A, Mentré F, Muselle C, Nordgren R, Nyberg HB, Parra-Guillén ZP, Pasotti L, Rode-Kristensen N, Sardu ML, Smith GR, Swat MJ, Terranova N, Yngman G, Yvon F, Holford N; DDMoRe consortium. Smith MK, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):647-650. doi: 10.1002/psp4.12222. Epub 2017 Jul 12. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28643440 Free PMC article. No abstract available.

8

Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults.

Melin J, Parra-Guillen ZP, Hartung N, Huisinga W, Ross RJ, Whitaker MJ, Kloft C. Melin J, et al. Clin Pharmacokinet. 2018 Apr;57(4):515-527. doi: 10.1007/s40262-017-0575-8. Clin Pharmacokinet. 2018. PMID: 28762136

9

The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing.

Melin J, Hartung N, Parra-Guillen ZP, Whitaker MJ, Ross RJ, Kloft C. Melin J, et al. Clin Endocrinol (Oxf). 2019 Jul;91(1):33-40. doi: 10.1111/cen.13969. Epub 2019 Apr 9. Clin Endocrinol (Oxf). 2019. PMID: 30868607 Free article. Clinical Trial.

10

A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease.

Balbas-Martinez V, Asin-Prieto E, Parra-Guillen ZP, Troconiz IF. Balbas-Martinez V, et al. J Pharmacol Exp Ther. 2020 Mar;372(3):299-307. doi: 10.1124/jpet.119.260539. Epub 2019 Dec 10. J Pharmacol Exp Ther. 2020. PMID: 31822515

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