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241 results

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Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration.
Zhou Y, Medik YB, Patel B, Zamler DB, Chen S, Chapman T, Schneider S, Park EM, Babcock RL, Chrisikos TT, Kahn LM, Dyevoich AM, Pineda JE, Wong MC, Mishra AK, Cass SH, Cogdill AP, Johnson DH, Johnson SB, Wani K, Ledesma DA, Hudgens CW, Wang J, Wadud Khan MA, Peterson CB, Joon AY, Peng W, Li HS, Arora R, Tang X, Raso MG, Zhang X, Foo WC, Tetzlaff MT, Diehl GE, Clise-Dwyer K, Whitley EM, Gubin MM, Allison JP, Hwu P, Ajami NJ, Diab A, Wargo JA, Watowich SS. Zhou Y, et al. Among authors: park em. J Exp Med. 2023 Feb 6;220(2):e20221333. doi: 10.1084/jem.20221333. Epub 2022 Nov 11. J Exp Med. 2023. PMID: 36367776 Free PMC article.
Targeting the gut and tumor microbiota in cancer.
Park EM, Chelvanambi M, Bhutiani N, Kroemer G, Zitvogel L, Wargo JA. Park EM, et al. Nat Med. 2022 Apr;28(4):690-703. doi: 10.1038/s41591-022-01779-2. Epub 2022 Apr 19. Nat Med. 2022. PMID: 35440726 Review.
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance.
Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Park JS, et al. Among authors: park em. Nature. 2023 May;617(7960):377-385. doi: 10.1038/s41586-023-06026-3. Epub 2023 May 3. Nature. 2023. PMID: 37138075 Free PMC article.
STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response.
Patel B, Zhou Y, Babcock RL, Ma F, Zal MA, Kumar D, Medik YB, Kahn LM, Pineda JE, Park EM, Schneider SM, Tang X, Raso MG, Jeter CR, Zal T, Clise-Dwyer K, Keyomarsi K, Giancotti FG, Colla S, Watowich SS. Patel B, et al. Among authors: park em. Leukemia. 2024 May;38(5):1143-1155. doi: 10.1038/s41375-024-02218-6. Epub 2024 Mar 11. Leukemia. 2024. PMID: 38467768
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.
Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della Corte CM, Robson P, Swisher SG, Roth JA, Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA. Gay CM, et al. Among authors: park em. Cancer Cell. 2021 Mar 8;39(3):346-360.e7. doi: 10.1016/j.ccell.2020.12.014. Epub 2021 Jan 21. Cancer Cell. 2021. PMID: 33482121 Free PMC article.
Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology.
Stewart CA, Gay CM, Ramkumar K, Cargill KR, Cardnell RJ, Nilsson MB, Heeke S, Park EM, Kundu ST, Diao L, Wang Q, Shen L, Xi Y, Zhang B, Della Corte CM, Fan Y, Kundu K, Gao B, Avila K, Pickering CR, Johnson FM, Zhang J, Kadara H, Minna JD, Gibbons DL, Wang J, Heymach JV, Byers LA. Stewart CA, et al. Among authors: park em. J Thorac Oncol. 2021 Nov;16(11):1821-1839. doi: 10.1016/j.jtho.2021.07.002. Epub 2021 Jul 16. J Thorac Oncol. 2021. PMID: 34274504 Free PMC article.
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer.
Cargill KR, Stewart CA, Park EM, Ramkumar K, Gay CM, Cardnell RJ, Wang Q, Diao L, Shen L, Fan YH, Chan WK, Lorenzi PL, Oliver TG, Wang J, Byers LA. Cargill KR, et al. Among authors: park em. Cancer Metab. 2021 Sep 23;9(1):33. doi: 10.1186/s40170-021-00270-9. Cancer Metab. 2021. PMID: 34556188 Free PMC article.
Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology.
Stewart CA, Gay CM, Ramkumar K, Cargill KR, Cardnell RJ, Nilsson MB, Heeke S, Park EM, Kundu ST, Diao L, Wang Q, Shen L, Xi Y, Zhang B, Della Corte CM, Fan Y, Kundu K, Gao B, Avila K, Pickering CR, Johnson FM, Zhang J, Kadara H, Minna JD, Gibbons DL, Wang J, Heymach JV, Byers LA. Stewart CA, et al. Among authors: park em. bioRxiv [Preprint]. 2021 Jan 28:2020.05.28.122291. doi: 10.1101/2020.05.28.122291. bioRxiv. 2021. PMID: 32577652 Free PMC article. Updated. Preprint.
241 results