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HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide.
Cell Rep. 2023 Jul 25;42(7):112755. doi: 10.1016/j.celrep.2023.112755. Epub 2023 Jul 11.
Cell Rep. 2023.
PMID: 37436899
Free PMC article.
Clinical Trial.
Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose-escalation, phase 1 clinical trial.
Houser KV, Gaudinski MR, Happe M, Narpala S, Verardi R, Sarfo EK, Corrigan AR, Wu R, Rothwell RS, Novik L, Hendel CS, Gordon IJ, Berkowitz NM, Cartagena CT, Widge AT, Coates EE, Strom L, Hickman S, Conan-Cibotti M, Vazquez S, Trofymenko O, Plummer S, Stein J, Case CL, Nason M, Biju A, Parchment DK, Changela A, Cheng C, Duan H, Geng H, Teng IT, Zhou T, O'Connell S, Barry C, Carlton K, Gall JG, Flach B, Doria-Rose NA, Graham BS, Koup RA, McDermott AB, Mascola JR, Kwong PD, Ledgerwood JE; VRC 018 Study Team.
Houser KV, et al. Among authors: parchment dk.
EClinicalMedicine. 2022 Jun 1;48:101477. doi: 10.1016/j.eclinm.2022.101477. eCollection 2022 Jun.
EClinicalMedicine. 2022.
PMID: 35783486
Free PMC article.
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Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD.
Sastry M, et al. Among authors: parchment dk.
J Virol. 2023 May 31;97(5):e0160422. doi: 10.1128/jvi.01604-22. Epub 2023 Apr 26.
J Virol. 2023.
PMID: 37098956
Free PMC article.
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Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases.
Olia AS, Cheng C, Zhou T, Biju A, Harris DR, Changela A, Duan H, Ivleva VB, Kong WP, Ou L, Rawi R, Tsybovsky Y, Van Wazer DJ, Corrigan AR, Gonelli CA, Lee M, McKee K, Narpala S, O'Dell S, Parchment DK, Stancofski ED, Stephens T, Tan I, Teng IT, Wang S, Wei Q, Yang Y, Yang Z, Zhang B; VRC Production Program; Novak J, Renfrow MB, Doria-Rose NA, Koup RA, McDermott AB, Gall JG, Lei QP, Mascola JR, Kwong PD.
Olia AS, et al. Among authors: parchment dk.
iScience. 2023 Jul 15;26(8):107403. doi: 10.1016/j.isci.2023.107403. eCollection 2023 Aug 18.
iScience. 2023.
PMID: 37554450
Free PMC article.
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Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base.
Duan H, Corrigan AR, Cheng C, Biju A, Gonelli CA, Olia AS, Teng IT, Xu K, O'Dell S, Narpala S, Castro M, Serebryannyy L, Wang J, Parchment DK, Sarfo EK, van Schooten J, Todd JP, Wang S, Harris DR, Geng H, Jafari AJ; VRC Production Program; Woodward RA, Doria-Rose NA, Foulds KE, McDermott AB, van Gils MJ, Koup RA, Pierson TC, Kwong PD, Mascola JR.
Duan H, et al. Among authors: parchment dk.
iScience. 2024 Jan 11;27(2):108877. doi: 10.1016/j.isci.2024.108877. eCollection 2024 Feb 16.
iScience. 2024.
PMID: 38318357
Free PMC article.
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Volatile profiling distinguishes Streptococcus pyogenes from other respiratory streptococcal species.
Berna AZ, Merriman JA, Mellett L, Parchment DK, Caparon MG, Odom John AR.
Berna AZ, et al. Among authors: parchment dk.
mSphere. 2023 Oct 24;8(5):e0019423. doi: 10.1128/msphere.00194-23. Epub 2023 Oct 4.
mSphere. 2023.
PMID: 37791788
Free PMC article.
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