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Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.
Park JE, Kirsch K, Lee H, Oliva P, Ahn JI, Ravishankar H, Zeng Y, Fox SD, Kirby SA, Badhwar P, Andresson T, Jacobson KA, Lee KS. Park JE, et al. Among authors: oliva p. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305037120. doi: 10.1073/pnas.2305037120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603740 Free PMC article.
Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs.
Park JE, Lee H, Oliva P, Kirsch K, Kim B, Ahn JI, Alverez CN, Gaikwad S, Krausz KW, O'Connor R, Rai G, Simeonov A, Mock BA, Gonzalez FJ, Lee KS, Jacobson KA. Park JE, et al. Among authors: oliva p. ACS Pharmacol Transl Sci. 2023 Feb 20;6(3):422-446. doi: 10.1021/acsptsci.2c00250. eCollection 2023 Mar 10. ACS Pharmacol Transl Sci. 2023. PMID: 36926457 Free PMC article.
Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities.
Romagnoli R, Oliva P, Prencipe F, Manfredini S, Budassi F, Brancale A, Ferla S, Hamel E, Corallo D, Aveic S, Manfreda L, Mariotto E, Bortolozzi R, Viola G. Romagnoli R, et al. Among authors: oliva p. Pharmaceuticals (Basel). 2022 Aug 21;15(8):1031. doi: 10.3390/ph15081031. Pharmaceuticals (Basel). 2022. PMID: 36015179 Free PMC article.
Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.
Scortichini M, Idris RM, Moschütz S, Keim A, Salmaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA. Scortichini M, et al. Among authors: oliva p. J Med Chem. 2022 Feb 10;65(3):2409-2433. doi: 10.1021/acs.jmedchem.1c01852. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080883 Free PMC article.
27 results