Paluszkiewicz E - Search Results

1

pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy.

Pilch J, Potęga A, Kowalczyk A, Kasprzak A, Kowalik P, Bujak P, Paluszkiewicz E, Augustin E, Nowicka AM. Pilch J, et al. Among authors: paluszkiewicz e. Pharmaceutics. 2023 Jan 6;15(1):201. doi: 10.3390/pharmaceutics15010201. Pharmaceutics. 2023. PMID: 36678830 Free PMC article.

2

The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748.

Borowa-Mazgaj B, Mróz A, Augustin E, Paluszkiewicz E, Mazerska Z. Borowa-Mazgaj B, et al. Among authors: paluszkiewicz e. Biochem Pharmacol. 2017 Oct 15;142:21-38. doi: 10.1016/j.bcp.2017.06.124. Epub 2017 Jun 21. Biochem Pharmacol. 2017. PMID: 28645477

3

Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes.

Paluszkiewicz E, Horowska B, Borowa-Mazgaj B, Peszyńska-Sularz G, Paradziej-Łukowicz J, Augustin E, Konopa J, Mazerska Z. Paluszkiewicz E, et al. Eur J Med Chem. 2020 Oct 15;204:112599. doi: 10.1016/j.ejmech.2020.112599. Epub 2020 Jul 16. Eur J Med Chem. 2020. PMID: 32736230

4

Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053.

Potęga A, Paczkowski S, Paluszkiewicz E, Mazerska Z. Potęga A, et al. Among authors: paluszkiewicz e. J Pharm Biomed Anal. 2021 Apr 15;197:113970. doi: 10.1016/j.jpba.2021.113970. Epub 2021 Feb 13. J Pharm Biomed Anal. 2021. PMID: 33618132

5

Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells.

Pilch J, Kowalik P, Kowalczyk A, Bujak P, Kasprzak A, Paluszkiewicz E, Augustin E, Nowicka AM. Pilch J, et al. Among authors: paluszkiewicz e. Int J Mol Sci. 2022 Jan 23;23(3):1261. doi: 10.3390/ijms23031261. Int J Mol Sci. 2022. PMID: 35163186 Free PMC article.

6

Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity.

Potęga A, Göldner V, Niehaves E, Paluszkiewicz E, Karst U. Potęga A, et al. Among authors: paluszkiewicz e. J Pharm Biomed Anal. 2023 Oct 25;235:115607. doi: 10.1016/j.jpba.2023.115607. Epub 2023 Jul 26. J Pharm Biomed Anal. 2023. PMID: 37523868

7

In Vitro Enzyme Kinetics and NMR-Based Product Elucidation for Glutathione S-Conjugation of the Anticancer Unsymmetrical Bisacridine C-2028 in Liver Microsomes and Cytosol: Major Role of Glutathione S-Transferase M1-1 Isoenzyme.

Potęga A, Rafalska D, Kazimierczyk D, Kosno M, Pawłowicz A, Andrałojć W, Paluszkiewicz E, Laskowski T. Potęga A, et al. Among authors: paluszkiewicz e. Molecules. 2023 Sep 26;28(19):6812. doi: 10.3390/molecules28196812. Molecules. 2023. PMID: 37836655 Free PMC article.

8

Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures.

Kulesza J, Paluszkiewicz E, Augustin E. Kulesza J, et al. Among authors: paluszkiewicz e. Int J Mol Sci. 2023 Oct 30;24(21):15780. doi: 10.3390/ijms242115780. Int J Mol Sci. 2023. PMID: 37958764 Free PMC article.

9

The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies.

Laskowski T, Kosno M, Andrałojć W, Frackowiak JE, Borzyszkowska-Bukowska J, Szczeblewski P, Radoń N, Świerżewska M, Woźny A, Paluszkiewicz E, Mazerska Z. Laskowski T, et al. Among authors: paluszkiewicz e. Sci Rep. 2023 Mar 1;13(1):3431. doi: 10.1038/s41598-023-30587-y. Sci Rep. 2023. PMID: 36859494 Free PMC article.

10

Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity.

Gabriel I, Rząd K, Paluszkiewicz E, Kozłowska-Tylingo K. Gabriel I, et al. Among authors: paluszkiewicz e. Pathogens. 2021 Feb 9;10(2):189. doi: 10.3390/pathogens10020189. Pathogens. 2021. PMID: 33572407 Free PMC article.

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