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Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor β.
Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. Christmann RB, et al. Among authors: padilla c. Arthritis Rheum. 2013 May;65(5):1335-46. doi: 10.1002/art.37859. Arthritis Rheum. 2013. PMID: 23335246 Free PMC article.
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.
Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R. Rice LM, et al. J Clin Invest. 2015 Jul 1;125(7):2795-807. doi: 10.1172/JCI77958. Epub 2015 Jun 22. J Clin Invest. 2015. PMID: 26098215 Free PMC article. Clinical Trial.
Prediction of disability-free survival in healthy older people.
Neumann JT, Thao LTP, Murray AM, Callander E, Carr PR, Nelson MR, Wolfe R, Woods RL, Reid CM, Shah RC, Newman AB, Williamson JD, Tonkin AM, McNeil JJ; ASPREE investigators. Neumann JT, et al. Geroscience. 2022 Jun;44(3):1641-1655. doi: 10.1007/s11357-022-00547-x. Epub 2022 Apr 14. Geroscience. 2022. PMID: 35420334 Free PMC article. Clinical Trial.
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