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Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K. Napolitano V, et al. Among authors: pachota m. Cell Chem Biol. 2022 May 19;29(5):774-784.e8. doi: 10.1016/j.chembiol.2021.11.006. Epub 2022 Jan 11. Cell Chem Biol. 2022. PMID: 35021060 Free PMC article.
Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Dömling A, Dubin G, Holak TA. Skalniak L, et al. Among authors: pachota m. Oncotarget. 2017 Aug 7;8(42):72167-72181. doi: 10.18632/oncotarget.20050. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069777 Free PMC article.
Cat flu: Broad spectrum polymeric antivirals.
Synowiec A, Gryniuk I, Pachota M, Strzelec Ł, Roman O, Kłysik-Trzciańska K, Zając M, Drebot I, Gula K, Andruchowicz A, Rajfur Z, Szczubiałka K, Nowakowska M, Pyrc K. Synowiec A, et al. Among authors: pachota m. Antiviral Res. 2019 Oct;170:104563. doi: 10.1016/j.antiviral.2019.104563. Epub 2019 Jul 17. Antiviral Res. 2019. PMID: 31325462
Novel inhibitors of HSV-1 protease effective in vitro and in vivo.
Pachota M, Grzywa R, Iwanejko J, Synowiec A, Iwan D, Kamińska K, Skoreński M, Bielecka E, Szczubiałka K, Nowakowska M, Mackereth CD, Wojaczyńska E, Sieńczyk M, Pyrć K. Pachota M, et al. Antiviral Res. 2023 May;213:105604. doi: 10.1016/j.antiviral.2023.105604. Epub 2023 Apr 11. Antiviral Res. 2023. PMID: 37054954 Free article.
Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A. Matsuda A, et al. Among authors: pachota m. Nucleic Acids Res. 2024 Mar 18:gkae165. doi: 10.1093/nar/gkae165. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38499483