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Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. Nation DA, et al. Among authors: pachicano m. Nat Med. 2019 Feb;25(2):270-276. doi: 10.1038/s41591-018-0297-y. Epub 2019 Jan 14. Nat Med. 2019. PMID: 30643288 Free PMC article.
A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid.
Sweeney MD, Sagare AP, Pachicano M, Harrington MG, Joe E, Chui HC, Schneider LS, Montagne A, Ringman JM, Fagan AM, Morris JC, Pa J, Nation DA, Toga AW, Zlokovic BV. Sweeney MD, et al. Among authors: pachicano m. Alzheimers Dement. 2020 Jun;16(6):821-830. doi: 10.1002/alz.12061. Epub 2020 Apr 16. Alzheimers Dement. 2020. PMID: 32301266 Free PMC article.
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. Montagne A, et al. Among authors: pachicano m. Nature. 2020 May;581(7806):71-76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29. Nature. 2020. PMID: 32376954 Free PMC article.
Machine Learning Classification of Alzheimer's Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions.
Stephen TL, Korobkova L, Breningstall B, Nguyen K, Mehta S, Pachicano M, Jones KT, Hawes D, Cabeen RP, Bienkowski MS. Stephen TL, et al. Among authors: pachicano m. bioRxiv [Preprint]. 2023 Jun 5:2023.05.31.543117. doi: 10.1101/2023.05.31.543117. bioRxiv. 2023. PMID: 37333119 Free PMC article. Preprint.