Pace P - Search Results

1

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.

Summa V, Petrocchi A, Bonelli F, Crescenzi B, Donghi M, Ferrara M, Fiore F, Gardelli C, Gonzalez Paz O, Hazuda DJ, Jones P, Kinzel O, Laufer R, Monteagudo E, Muraglia E, Nizi E, Orvieto F, Pace P, Pescatore G, Scarpelli R, Stillmock K, Witmer MV, Rowley M. Summa V, et al. Among authors: pace p. J Med Chem. 2008 Sep 25;51(18):5843-55. doi: 10.1021/jm800245z. J Med Chem. 2008. PMID: 18763751

2

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. Among authors: pace p. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

3

4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.

Summa V, Petrocchi A, Matassa VG, Gardelli C, Muraglia E, Rowley M, Paz OG, Laufer R, Monteagudo E, Pace P. Summa V, et al. Among authors: pace p. J Med Chem. 2006 Nov 16;49(23):6646-9. doi: 10.1021/jm060854f. J Med Chem. 2006. PMID: 17154493

4

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V. Pace P, et al. J Med Chem. 2007 May 3;50(9):2225-39. doi: 10.1021/jm070027u. Epub 2007 Apr 12. J Med Chem. 2007. PMID: 17428043

5

Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.

Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, Pace P, Pescatore G, Poma M, Ferreira Mdel R, Scarpelli R, Homnick CF, Ikemoto N, Alfieri A, Verdirame M, Bonelli F, Paz OG, Taliani M, Monteagudo E, Pesci S, Laufer R, Felock P, Stillmock KA, Hazuda D, Rowley M, Summa V. Gardelli C, et al. Among authors: pace p. J Med Chem. 2007 Oct 4;50(20):4953-75. doi: 10.1021/jm0704705. Epub 2007 Sep 8. J Med Chem. 2007. PMID: 17824681

6

Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.

Di Francesco ME, Pace P, Fiore F, Naimo F, Bonelli F, Rowley M, Summa V. Di Francesco ME, et al. Among authors: pace p. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2709-13. doi: 10.1016/j.bmcl.2008.03.017. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18362069

7

4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.

Pace P, Spieser SA, Summa V. Pace P, et al. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3865-9. doi: 10.1016/j.bmcl.2008.06.056. Epub 2008 Jun 20. Bioorg Med Chem Lett. 2008. PMID: 18595690

8

Integrase inhibitors for the treatment of HIV infection.

Pace P, Rowley M. Pace P, et al. Curr Opin Drug Discov Devel. 2008 Jul;11(4):471-9. Curr Opin Drug Discov Devel. 2008. PMID: 18600564 Review.

9

Novel macrocyclic inhibitors of hepatitis C NS3/4A protease featuring a 2-amino-1,3-thiazole as a P4 carbamate replacement.

Di Francesco ME, Dessole G, Nizi E, Pace P, Koch U, Fiore F, Pesci S, Di Muzio J, Monteagudo E, Rowley M, Summa V. Di Francesco ME, et al. Among authors: pace p. J Med Chem. 2009 Nov 26;52(22):7014-28. doi: 10.1021/jm900524b. J Med Chem. 2009. PMID: 19856919

10

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.

Pace P, Nizi E, Pacini B, Pesci S, Matassa V, De Francesco R, Altamura S, Summa V. Pace P, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3257-61. doi: 10.1016/j.bmcl.2004.03.087. Bioorg Med Chem Lett. 2004. PMID: 15149686

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