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Page 1
Telomerase as a Therapeutic Target in Cardiovascular Disease.
Hoffmann J, Richardson G, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. Hoffmann J, et al. Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1047-1061. doi: 10.1161/ATVBAHA.120.315695. Epub 2021 Jan 28. Arterioscler Thromb Vasc Biol. 2021. PMID: 33504179 Free article. Review.
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery.
Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep OE, Santin Y, Mialet-Perez J, Andrew Owens W, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Dookun E, et al. Aging Cell. 2020 Oct;19(10):e13249. doi: 10.1111/acel.13249. Epub 2020 Sep 29. Aging Cell. 2020. PMID: 32996233 Free PMC article.
Therapeutic Potential of Senolytics in Cardiovascular Disease.
Dookun E, Passos JF, Arthur HM, Richardson GD. Dookun E, et al. Cardiovasc Drugs Ther. 2022 Feb;36(1):187-196. doi: 10.1007/s10557-020-07075-w. Epub 2020 Sep 26. Cardiovasc Drugs Ther. 2022. PMID: 32979174 Free PMC article. Review.
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Anderson R, et al. EMBO J. 2019 Mar 1;38(5):e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. EMBO J. 2019. PMID: 30737259 Free PMC article.