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Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.
Yu N, Kozlowski JM, Park II, Chen L, Zhang Q, Xu D, Doll JA, Crawford SE, Brendler CB, Lee C. Yu N, et al. Urology. 2010 Dec;76(6):1519.e8-13. doi: 10.1016/j.urology.2010.03.061. Epub 2010 Oct 27. Urology. 2010. PMID: 21030067 Free PMC article.