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The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.
Cyr Y, Bozal FK, Barcia Durán JG, Newman AAC, Amadori L, Smyrnis P, Gourvest M, Das D, Gildea M, Kaur R, Zhang T, Wang KM, Von Itter R, Schlegel PM, Dupuis SD, Sanchez BF, Schmidt AM, Fisher EA, van Solingen C, Giannarelli C, Moore KJ. Cyr Y, et al. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2400675121. doi: 10.1073/pnas.2400675121. Epub 2024 Apr 2. Proc Natl Acad Sci U S A. 2024. PMID: 38564634 Free PMC article.
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis.
Amadori L, Calcagno C, Fernandez DM, Koplev S, Fernandez N, Kaur R, Mury P, Khan NS, Sajja S, Shamailova R, Cyr Y, Jeon M, Hill CA, Chong PS, Naidu S, Sakurai K, Ghotbi AA, Soler R, Eberhardt N, Rahman A, Faries P, Moore KJ, Fayad ZA, Ma'ayan A, Giannarelli C. Amadori L, et al. Nat Cardiovasc Res. 2023 Jun;2(6):550-571. doi: 10.1038/s44161-023-00278-y. Epub 2023 Jun 8. Nat Cardiovasc Res. 2023. PMID: 37771373 Free PMC article.
Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor.
Ducarouge B, Redavid AR, Victoor C, Chira R, Fonseca A, Hervieu M, Bergé R, Lengrand J, Vieugué P, Neves D, Goddard I, Richaud M, Laval PA, Rama N, Goldschneider D, Paradisi A, Gourdin N, Chabaud S, Treilleux I, Gadot N, Ray-Coquard I, Depil S, Decaudin D, Némati F, Marangoni E, Mery-Lamarche E, Génestie C, Tabone-Eglinger S, Devouassoux-Shisheboran M, Moore KJ, Gibert B, Mehlen P, Bernet A. Ducarouge B, et al. Cell Death Differ. 2023 Oct;30(10):2201-2212. doi: 10.1038/s41418-023-01209-x. Epub 2023 Aug 26. Cell Death Differ. 2023. PMID: 37633969
Pharmacological antagonism of receptor for advanced glycation end products signaling promotes thermogenesis, healthful body mass and composition, and metabolism in mice.
Wilson RA, Arivazhagan L, Ruiz HH, Zhou B, Qian K, Manigrasso MB, Bernadin R, Mangar K, Shekhtman A, Li H, Ramasamy R, Schmidt AM. Wilson RA, et al. Obesity (Silver Spring). 2023 Jul;31(7):1825-1843. doi: 10.1002/oby.23774. Epub 2023 May 25. Obesity (Silver Spring). 2023. PMID: 37231626
DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice.
Senatus L, Egaña-Gorroño L, López-Díez R, Bergaya S, Aranda JF, Amengual J, Arivazhagan L, Manigrasso MB, Yepuri G, Nimma R, Mangar KN, Bernadin R, Zhou B, Gugger PF, Li H, Friedman RA, Theise ND, Shekhtman A, Fisher EA, Ramasamy R, Schmidt AM. Senatus L, et al. Commun Biol. 2023 Mar 17;6(1):280. doi: 10.1038/s42003-023-04643-2. Commun Biol. 2023. PMID: 36932214 Free PMC article.
64 results