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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models.
Kaiser FK, Hernandez MG, Krüger N, Englund E, Du W, Mykytyn AZ, Raadsen MP, Lamers MM, Rodrigues Ianiski F, Shamorkina TM, Snijder J, Armando F, Beythien G, Ciurkiewicz M, Schreiner T, Gruber-Dujardin E, Bleyer M, Batura O, Erffmeier L, Hinkel R, Rocha C, Mirolo M, Drabek D, Bosch BJ, Emalfarb M, Valbuena N, Tchelet R, Baumgärtner W, Saloheimo M, Pöhlmann S, Grosveld F, Haagmans BL, Osterhaus ADME. Kaiser FK, et al. Among authors: pohlmann s. Nat Commun. 2024 Mar 14;15(1):2319. doi: 10.1038/s41467-024-46443-0. Nat Commun. 2024. PMID: 38485931 Free PMC article.
Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins.
Plegge T, Spiegel M, Krüger N, Nehlmeier I, Winkler M, González Hernández M, Pöhlmann S. Plegge T, et al. Among authors: pohlmann s. PLoS One. 2019 Apr 11;14(4):e0214968. doi: 10.1371/journal.pone.0214968. eCollection 2019. PLoS One. 2019. PMID: 30973897 Free PMC article.
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.
Hoffmann M, Mösbauer K, Hofmann-Winkler H, Kaul A, Kleine-Weber H, Krüger N, Gassen NC, Müller MA, Drosten C, Pöhlmann S. Hoffmann M, et al. Among authors: pohlmann s. Nature. 2020 Sep;585(7826):588-590. doi: 10.1038/s41586-020-2575-3. Epub 2020 Jul 22. Nature. 2020. PMID: 32698190
SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization.
Hoffmann M, Zhang L, Krüger N, Graichen L, Kleine-Weber H, Hofmann-Winkler H, Kempf A, Nessler S, Riggert J, Winkler MS, Schulz S, Jäck HM, Pöhlmann S. Hoffmann M, et al. Among authors: pohlmann s. Cell Rep. 2021 Apr 20;35(3):109017. doi: 10.1016/j.celrep.2021.109017. Epub 2021 Apr 3. Cell Rep. 2021. PMID: 33857422 Free PMC article.
The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection.
Krüger N, Rocha C, Runft S, Krüger J, Färber I, Armando F, Leitzen E, Brogden G, Gerold G, Pöhlmann S, Hoffmann M, Baumgärtner W. Krüger N, et al. Among authors: pohlmann s. Int J Mol Sci. 2021 Sep 30;22(19):10636. doi: 10.3390/ijms221910636. Int J Mol Sci. 2021. PMID: 34638978 Free PMC article.
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties.
Hempel T, Elez K, Krüger N, Raich L, Shrimp JH, Danov O, Jonigk D, Braun A, Shen M, Hall MD, Pöhlmann S, Hoffmann M, Noé F. Hempel T, et al. Among authors: pohlmann s. Chem Sci. 2021 Aug 26;12(38):12600-12609. doi: 10.1039/d1sc01494c. eCollection 2021 Oct 6. Chem Sci. 2021. PMID: 34703545 Free PMC article.
314 results