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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Trussell DT, Li KX, Pöhlmann ML, Mackert S, Geiger TM, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Próchnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA Jr, Hausch F, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC. Hartmann J, et al. Among authors: pohlmann ml. Nat Commun. 2024 Mar 25;15(1):2635. doi: 10.1038/s41467-024-46953-x. Nat Commun. 2024. PMID: 38528004 Free PMC article.
Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.
Hartmann J, Dedic N, Pöhlmann ML, Häusl A, Karst H, Engelhardt C, Westerholz S, Wagner KV, Labermaier C, Hoeijmakers L, Kertokarijo M, Chen A, Joëls M, Deussing JM, Schmidt MV. Hartmann J, et al. Among authors: pohlmann ml. Mol Psychiatry. 2017 Mar;22(3):466-475. doi: 10.1038/mp.2016.87. Epub 2016 May 31. Mol Psychiatry. 2017. PMID: 27240530
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.
Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM. Dedic N, et al. Among authors: pohlmann ml. Mol Psychiatry. 2018 Mar;23(3):533-543. doi: 10.1038/mp.2017.133. Epub 2017 Jul 11. Mol Psychiatry. 2018. PMID: 28696432 Free PMC article.
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.
Balsevich G, Häusl AS, Meyer CW, Karamihalev S, Feng X, Pöhlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C, Hafner K, Mao T, Breitsamer M, Theodoropoulou M, Namendorf C, Uhr M, Paez-Pereda M, Winter G, Hausch F, Chen A, Tschöp MH, Rein T, Gassen NC, Schmidt MV. Balsevich G, et al. Among authors: pohlmann ml. Nat Commun. 2017 Nov 23;8(1):1725. doi: 10.1038/s41467-017-01783-y. Nat Commun. 2017. PMID: 29170369 Free PMC article.
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM. Dedic N, et al. Among authors: pohlmann ml. Nat Neurosci. 2018 Jun;21(6):803-807. doi: 10.1038/s41593-018-0151-z. Epub 2018 May 21. Nat Neurosci. 2018. PMID: 29786085 Free PMC article.
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice.
Häusl AS, Brix LM, Hartmann J, Pöhlmann ML, Lopez JP, Menegaz D, Brivio E, Engelhardt C, Roeh S, Bajaj T, Rudolph L, Stoffel R, Hafner K, Goss HM, Reul JMHM, Deussing JM, Eder M, Ressler KJ, Gassen NC, Chen A, Schmidt MV. Häusl AS, et al. Among authors: pohlmann ml. Mol Psychiatry. 2021 Jul;26(7):3060-3076. doi: 10.1038/s41380-021-01044-x. Epub 2021 Mar 1. Mol Psychiatry. 2021. PMID: 33649453 Free PMC article.
17 results