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One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies.
Epigenomes. 2021 Oct 8;5(4):22. doi: 10.3390/epigenomes5040022.
Epigenomes. 2021.
PMID: 34968247
Free PMC article.
Review.
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.
Agarwal P, Alzrigat M, Párraga AA, Enroth S, Singh U, Ungerstedt J, Österborg A, Brown PJ, Ma A, Jin J, Nilsson K, Öberg F, Kalushkova A, Jernberg-Wiklund H.
Agarwal P, et al. Among authors: parraga aa.
Oncotarget. 2016 Feb 9;7(6):6809-23. doi: 10.18632/oncotarget.6843.
Oncotarget. 2016.
PMID: 26755663
Free PMC article.
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
Alzrigat M, Párraga AA, Agarwal P, Zureigat H, Österborg A, Nahi H, Ma A, Jin J, Nilsson K, Öberg F, Kalushkova A, Jernberg-Wiklund H.
Alzrigat M, et al. Among authors: parraga aa.
Oncotarget. 2017 Feb 7;8(6):10213-10224. doi: 10.18632/oncotarget.14378.
Oncotarget. 2017.
PMID: 28052011
Free PMC article.
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Epigenetics in multiple myeloma: From mechanisms to therapy.
Alzrigat M, Párraga AA, Jernberg-Wiklund H.
Alzrigat M, et al. Among authors: parraga aa.
Semin Cancer Biol. 2018 Aug;51:101-115. doi: 10.1016/j.semcancer.2017.09.007. Epub 2017 Sep 27.
Semin Cancer Biol. 2018.
PMID: 28962927
Review.
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The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains.
Alzrigat M, Párraga AA, Majumder MM, Ma A, Jin J, Österborg A, Nahi H, Nilsson K, Heckman CA, Öberg F, Kalushkova A, Jernberg-Wiklund H.
Alzrigat M, et al. Among authors: parraga aa.
Oncotarget. 2017 Oct 20;8(61):103731-103743. doi: 10.18632/oncotarget.21909. eCollection 2017 Nov 28.
Oncotarget. 2017.
PMID: 29262596
Free PMC article.
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PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma.
Nylund P, Garrido-Zabala B, Párraga AA, Vasquez L, Pyl PT, Harinck GM, Ma A, Jin J, Öberg F, Kalushkova A, Wiklund HJ.
Nylund P, et al. Among authors: parraga aa.
Haematologica. 2024 Feb 1;109(2):567-577. doi: 10.3324/haematol.2023.282965.
Haematologica. 2024.
PMID: 37496441
Free PMC article.
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