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Treatment of obesity with celastrol.
Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Liu J, et al. Among authors: ozcan u. Cell. 2015 May 21;161(5):999-1011. doi: 10.1016/j.cell.2015.05.011. Cell. 2015. PMID: 26000480 Free PMC article.
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.
Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Zhou Y, et al. Among authors: ozcan u. Nat Med. 2011 Mar;17(3):356-65. doi: 10.1038/nm.2293. Epub 2011 Feb 13. Nat Med. 2011. PMID: 21317886 Free PMC article.
Potential for therapeutic manipulation of the UPR in disease.
Park SW, Ozcan U. Park SW, et al. Among authors: ozcan u. Semin Immunopathol. 2013 May;35(3):351-73. doi: 10.1007/s00281-013-0370-z. Epub 2013 Apr 10. Semin Immunopathol. 2013. PMID: 23572207 Free PMC article. Review.
IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects.
Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. Feng X, et al. Among authors: ozcan u. Nat Med. 2019 Apr;25(4):575-582. doi: 10.1038/s41591-019-0358-x. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833749 Free PMC article.
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction.
Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Liu J, et al. Among authors: ozcan u. Cell. 2016 Nov 3;167(4):1052-1066.e18. doi: 10.1016/j.cell.2016.10.015. Cell. 2016. PMID: 27814504 Free PMC article.
66 results