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Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH. Eschweiler S, et al. Among authors: ottensmeier ch. Nature. 2022 May;605(7911):741-746. doi: 10.1038/s41586-022-04685-2. Epub 2022 May 4. Nature. 2022. PMID: 35508656 Free PMC article. Clinical Trial.
DNA vaccines to attack cancer.
Stevenson FK, Ottensmeier CH, Johnson P, Zhu D, Buchan SL, McCann KJ, Roddick JS, King AT, McNicholl F, Savelyeva N, Rice J. Stevenson FK, et al. Among authors: ottensmeier ch. Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2(Suppl 2):14646-52. doi: 10.1073/pnas.0404896101. Epub 2004 Aug 3. Proc Natl Acad Sci U S A. 2004. PMID: 15292504 Free PMC article. Review.
Idiotype gene rescue in follicular lymphoma.
McCann K, Sahota SS, Stevenson FK, Ottensmeier CH. McCann K, et al. Among authors: ottensmeier ch. Methods Mol Med. 2005;115:145-71. doi: 10.1385/1-59259-936-2:145. Methods Mol Med. 2005. PMID: 15998967
DNA fusion vaccines enter the clinic.
Stevenson FK, Mander A, Chudley L, Ottensmeier CH. Stevenson FK, et al. Among authors: ottensmeier ch. Cancer Immunol Immunother. 2011 Aug;60(8):1147-51. doi: 10.1007/s00262-011-1042-2. Epub 2011 Jun 5. Cancer Immunol Immunother. 2011. PMID: 21644035 Free PMC article. Review.
DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time.
Chudley L, McCann K, Mander A, Tjelle T, Campos-Perez J, Godeseth R, Creak A, Dobbyn J, Johnson B, Bass P, Heath C, Kerr P, Mathiesen I, Dearnaley D, Stevenson F, Ottensmeier C. Chudley L, et al. Cancer Immunol Immunother. 2012 Nov;61(11):2161-70. doi: 10.1007/s00262-012-1270-0. Epub 2012 May 22. Cancer Immunol Immunother. 2012. PMID: 22729556 Free PMC article. Clinical Trial.
The immune response in HPV+ oropharyngeal cancer.
King EV, Ottensmeier CH, Thomas GJ. King EV, et al. Among authors: ottensmeier ch. Oncoimmunology. 2014 Jan 1;3(1):e27254. doi: 10.4161/onci.27254. Oncoimmunology. 2014. PMID: 24575385 Free PMC article.
184 results