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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Loregger A, Raaben M, Nieuwenhuis J, Tan JME, Jae LT, van den Hengel LG, Hendrix S, van den Berg M, Scheij S, Song JY, Huijbers IJ, Kroese LJ, Ottenhoff R, van Weeghel M, van de Sluis B, Brummelkamp T, Zelcer N. Loregger A, et al. Among authors: ottenhoff r. Nat Commun. 2020 Feb 28;11(1):1128. doi: 10.1038/s41467-020-14811-1. Nat Commun. 2020. PMID: 32111832 Free PMC article.
Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity.
Pols TW, Ottenhoff R, Vos M, Levels JH, Quax PH, Meijers JC, Pannekoek H, Groen AK, de Vries CJ. Pols TW, et al. Among authors: ottenhoff r. Biochem Biophys Res Commun. 2008 Feb 22;366(4):910-6. doi: 10.1016/j.bbrc.2007.12.039. Epub 2007 Dec 18. Biochem Biophys Res Commun. 2008. PMID: 18086558
Regulation of intestinal LDLR by the LXR-IDOL axis.
van Loon NM, van Wouw SAE, Ottenhoff R, Nelson JK, Kingma J, Scheij S, Moeton M, Zelcer N. van Loon NM, et al. Among authors: ottenhoff r. Atherosclerosis. 2020 Dec;315:1-9. doi: 10.1016/j.atherosclerosis.2020.10.898. Epub 2020 Nov 9. Atherosclerosis. 2020. PMID: 33190106 Free article.
Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
van Wouw SAE, van den Berg M, El Ouraoui M, Meurs A, Kingma J, Ottenhoff R, Loix M, Hoeksema MA, Prange K, Pasterkamp G, Hendriks JJA, Bogie JFJ, van Klinken JB, Vaz FM, Jongejan A, de Winther MPJ, Zelcer N. van Wouw SAE, et al. Among authors: ottenhoff r. J Lipid Res. 2023 Feb;64(2):100325. doi: 10.1016/j.jlr.2022.100325. Epub 2022 Dec 31. J Lipid Res. 2023. PMID: 36592658 Free PMC article.
Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice.
van Loon NM, Ottenhoff R, Kooijman S, Moeton M, Scheij S, Roscam Abbing RLP, Gijbels MJJ, Levels JHM, Sorrentino V, Berbée JFP, Rensen PCN, Zelcer N. van Loon NM, et al. Among authors: ottenhoff r. Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1785-1795. doi: 10.1161/ATVBAHA.118.311168. Arterioscler Thromb Vasc Biol. 2018. PMID: 29903737 Free PMC article.
83 results