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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Trussell DT, Li KX, Pöhlmann ML, Mackert S, Geiger TM, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Próchnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA Jr, Hausch F, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC. Hartmann J, et al. Among authors: otten j. Nat Commun. 2024 Mar 25;15(1):2635. doi: 10.1038/s41467-024-46953-x. Nat Commun. 2024. PMID: 38528004 Free PMC article.
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Hartmann J, Bajaj T, Otten J, Klengel C, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Li K, Pöhlmann ML, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Próchnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC. Hartmann J, et al. Among authors: otten j. bioRxiv [Preprint]. 2023 Apr 3:2023.04.03.534570. doi: 10.1101/2023.04.03.534570. bioRxiv. 2023. PMID: 37066393 Free PMC article. Updated. Preprint.
Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients.
Lu C, Donners MMPC, de Baaij JBJ, Jin H, Otten JJT, Manca M, van Zonneveld AJ, Jukema JW, Kraaijeveld A, Kuiper J, Pasterkamp G, Mees B, Sluimer JC, Cavill R, Karel JMH, Goossens P, Biessen EAL. Lu C, et al. Among authors: otten jjt. Front Immunol. 2024 Feb 12;15:1286382. doi: 10.3389/fimmu.2024.1286382. eCollection 2024. Front Immunol. 2024. PMID: 38410507 Free PMC article.
Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Elsayed MSA, Blake JF, Boys ML, Brown E, Chapsal BD, Chicarelli MJ, Cook AW, Fell JB, Fischer JP, Hanson L, Lemieux C, Martinson MC, McCown J, McNulty OT, Mejia MJ, Neitzel NA, Otten JN, Rodriguez ME, Wilcox D, Wong CE, Zhou Y, Hinklin RJ. Elsayed MSA, et al. Among authors: otten jn. ACS Med Chem Lett. 2023 Nov 15;14(12):1673-1681. doi: 10.1021/acsmedchemlett.3c00310. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116446
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells.
Christ A, Maas SL, Jin H, Lu C, Legein B, Wijnands E, Temmerman L, Otten J, Isaacs A, Zenke M, Stoll M, Biessen EAL, van der Vorst EPC. Christ A, et al. Among authors: otten j. Free Radic Biol Med. 2024 Jan;210:406-415. doi: 10.1016/j.freeradbiomed.2023.11.044. Epub 2023 Dec 5. Free Radic Biol Med. 2024. PMID: 38061606 Free article.
409 results