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329 results

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Page 1
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.
Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I. Abe H, et al. Among authors: otsu k. Nat Commun. 2019 Jun 27;10(1):2824. doi: 10.1038/s41467-019-10859-w. Nat Commun. 2019. PMID: 31249305 Free PMC article.
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, Komuro I, Otsu K. Tamai T, et al. Among authors: otsu k. J Biol Chem. 2013 Apr 5;288(14):10176-10187. doi: 10.1074/jbc.M112.423640. Epub 2013 Feb 20. J Biol Chem. 2013. PMID: 23426372 Free PMC article.
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I. Arita Y, et al. Among authors: otsu k. Nat Commun. 2014 Jul 29;5:4552. doi: 10.1038/ncomms5552. Nat Commun. 2014. PMID: 25072663 Free PMC article.
Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes.
Sawaki D, Hou L, Tomida S, Sun J, Zhan H, Aizawa K, Son BK, Kariya T, Takimoto E, Otsu K, Conway SJ, Manabe I, Komuro I, Friedman SL, Nagai R, Suzuki T. Sawaki D, et al. Among authors: otsu k. Cardiovasc Res. 2015 Sep 1;107(4):420-30. doi: 10.1093/cvr/cvv155. Epub 2015 May 17. Cardiovasc Res. 2015. PMID: 25987545 Free PMC article.
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism.
Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y. Tian Z, et al. Among authors: otsu k. Nat Commun. 2016 Sep 28;7:13016. doi: 10.1038/ncomms13016. Nat Commun. 2016. PMID: 27677409 Free PMC article.
CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor.
Ishizuka M, Harada M, Nomura S, Ko T, Ikeda Y, Guo J, Bujo S, Yanagisawa-Murakami H, Satoh M, Yamada S, Kumagai H, Motozawa Y, Hara H, Fujiwara T, Sato T, Takeda N, Takeda N, Otsu K, Morita H, Toko H, Komuro I. Ishizuka M, et al. Among authors: otsu k. Sci Rep. 2021 Feb 9;11(1):3426. doi: 10.1038/s41598-021-83022-5. Sci Rep. 2021. PMID: 33564089 Free PMC article.
329 results