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New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models.
Di Sarno V, Giovannelli P, Medina-Peris A, Ciaglia T, Di Donato M, Musella S, Lauro G, Vestuto V, Smaldone G, Di Matteo F, Bifulco G, Castoria G, Migliaccio A, Fernandez-Carvajal A, Campiglia P, Gomez-Monterrey I, Ostacolo C, Bertamino A. Di Sarno V, et al. Among authors: ostacolo c. Eur J Med Chem. 2022 Aug 5;238:114435. doi: 10.1016/j.ejmech.2022.114435. Epub 2022 May 12. Eur J Med Chem. 2022. PMID: 35598411
Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators.
Bertamino A, Ostacolo C, Ambrosino P, Musella S, Di Sarno V, Ciaglia T, Soldovieri MV, Iraci N, Fernandez Carvajal A, de la Torre-Martinez R, Ferrer-Montiel A, Gonzalez Muniz R, Novellino E, Taglialatela M, Campiglia P, Gomez-Monterrey I. Bertamino A, et al. Among authors: ostacolo c. J Med Chem. 2016 Mar 10;59(5):2179-91. doi: 10.1021/acs.jmedchem.5b01914. Epub 2016 Feb 17. J Med Chem. 2016. PMID: 26847872 Free article.
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme.
Lauro G, Tortorella P, Bertamino A, Ostacolo C, Koeberle A, Fischer K, Bruno I, Terracciano S, Gomez-Monterrey IM, Tauro M, Loiodice F, Novellino E, Riccio R, Werz O, Campiglia P, Bifulco G. Lauro G, et al. Among authors: ostacolo c. ChemMedChem. 2016 Mar 17;11(6):612-9. doi: 10.1002/cmdc.201500598. Epub 2016 Feb 24. ChemMedChem. 2016. PMID: 26915684
Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
Musella S, di Sarno V, Ciaglia T, Sala M, Spensiero A, Scala MC, Ostacolo C, Andrei G, Balzarini J, Snoeck R, Novellino E, Campiglia P, Bertamino A, Gomez-Monterrey IM. Musella S, et al. Among authors: ostacolo c. Eur J Med Chem. 2016 Nov 29;124:773-781. doi: 10.1016/j.ejmech.2016.09.014. Epub 2016 Sep 7. Eur J Med Chem. 2016. PMID: 27639368 Free PMC article.
Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening.
Lauro G, Manfra M, Pedatella S, Fischer K, Cantone V, Terracciano S, Bertamino A, Ostacolo C, Gomez-Monterrey I, De Nisco M, Riccio R, Novellino E, Werz O, Campiglia P, Bifulco G. Lauro G, et al. Among authors: ostacolo c. Eur J Med Chem. 2017 Jan 5;125:278-287. doi: 10.1016/j.ejmech.2016.09.042. Epub 2016 Sep 14. Eur J Med Chem. 2017. PMID: 27688183
65 results