Osorio FG - Search Results

1

Splicing-directed therapy in a new mouse model of human accelerated aging.

Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C. Osorio FG, et al. Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847. Sci Transl Med. 2011. PMID: 22030750

2

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, Cadiñanos J, Osorio FG, Foray N, Cobo J, de Carlos F, Lévy N, Freije JM, López-Otín C. Varela I, et al. Among authors: osorio fg. Nat Med. 2008 Jul;14(7):767-72. doi: 10.1038/nm1786. Epub 2008 Jun 29. Nat Med. 2008. PMID: 18587406

3

Accelerated ageing: from mechanism to therapy through animal models.

Osorio FG, Obaya AJ, López-Otín C, Freije JM. Osorio FG, et al. Transgenic Res. 2009 Feb;18(1):7-15. doi: 10.1007/s11248-008-9226-z. Epub 2008 Nov 18. Transgenic Res. 2009. PMID: 19015945 Review.

4

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.

Osorio FG, Bárcena C, Soria-Valles C, Ramsay AJ, de Carlos F, Cobo J, Fueyo A, Freije JM, López-Otín C. Osorio FG, et al. Genes Dev. 2012 Oct 15;26(20):2311-24. doi: 10.1101/gad.197954.112. Epub 2012 Sep 26. Genes Dev. 2012. PMID: 23019125 Free PMC article.

5

NF-kB in premature aging.

Osorio FG, López-Otín C, Freije JM. Osorio FG, et al. Aging (Albany NY). 2012 Nov;4(11):726-7. doi: 10.18632/aging.100502. Aging (Albany NY). 2012. PMID: 23211391 Free PMC article. Review. No abstract available.

6

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Mariño G, Ugalde AP, Fernández AF, Osorio FG, Fueyo A, Freije JM, López-Otín C. Mariño G, et al. Among authors: osorio fg. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30. Proc Natl Acad Sci U S A. 2010. PMID: 20805469 Free PMC article.

7

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.

Osorio FG, Varela I, Lara E, Puente XS, Espada J, Santoro R, Freije JM, Fraga MF, López-Otín C. Osorio FG, et al. Aging Cell. 2010 Dec;9(6):947-57. doi: 10.1111/j.1474-9726.2010.00621.x. Epub 2010 Oct 21. Aging Cell. 2010. PMID: 20961378 Free article.

8

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.

Puente XS, Quesada V, Osorio FG, Cabanillas R, Cadiñanos J, Fraile JM, Ordóñez GR, Puente DA, Gutiérrez-Fernández A, Fanjul-Fernández M, Lévy N, Freije JM, López-Otín C. Puente XS, et al. Among authors: osorio fg. Am J Hum Genet. 2011 May 13;88(5):650-6. doi: 10.1016/j.ajhg.2011.04.010. Epub 2011 May 5. Am J Hum Genet. 2011. PMID: 21549337 Free PMC article.

9

A conserved splicing mechanism of the LMNA gene controls premature aging.

Lopez-Mejia IC, Vautrot V, De Toledo M, Behm-Ansmant I, Bourgeois CF, Navarro CL, Osorio FG, Freije JM, Stévenin J, De Sandre-Giovannoli A, Lopez-Otin C, Lévy N, Branlant C, Tazi J. Lopez-Mejia IC, et al. Among authors: osorio fg. Hum Mol Genet. 2011 Dec 1;20(23):4540-55. doi: 10.1093/hmg/ddr385. Epub 2011 Aug 29. Hum Mol Genet. 2011. PMID: 21875900

10

Cell autonomous and systemic factors in progeria development.

Osorio FG, Ugalde AP, Mariño G, Puente XS, Freije JM, López-Otín C. Osorio FG, et al. Biochem Soc Trans. 2011 Dec;39(6):1710-4. doi: 10.1042/BST20110677. Biochem Soc Trans. 2011. PMID: 22103512 Review.

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