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Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 Mpro Main Protease Inhibitors.
Peralta-Moreno MN, Anton-Muñoz V, Ortega-Alarcon D, Jimenez-Alesanco A, Vega S, Abian O, Velazquez-Campoy A, Thomson TM, Granadino-Roldán JM, Machicado C, Rubio-Martinez J. Peralta-Moreno MN, et al. Among authors: ortega alarcon d. Pharmaceuticals (Basel). 2023 Apr 13;16(4):585. doi: 10.3390/ph16040585. Pharmaceuticals (Basel). 2023. PMID: 37111342 Free PMC article.
MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply.
Di X, Ortega-Alarcon D, Kakumanu R, Iglesias-Fernandez J, Diaz L, Baidoo EEK, Velazquez-Campoy A, Rodríguez-Concepción M, Perez-Gil J. Di X, et al. Among authors: ortega alarcon d. Plant Commun. 2023 May 8;4(3):100512. doi: 10.1016/j.xplc.2022.100512. Epub 2022 Dec 26. Plant Commun. 2023. PMID: 36575800 Free PMC article.
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
Pinheiro F, Pallarès I, Peccati F, Sánchez-Morales A, Varejão N, Bezerra F, Ortega-Alarcon D, Gonzalez D, Osorio M, Navarro S, Velázquez-Campoy A, Almeida MR, Reverter D, Busqué F, Alibés R, Sodupe M, Ventura S. Pinheiro F, et al. Among authors: ortega alarcon d. J Med Chem. 2022 Nov 10;65(21):14673-14691. doi: 10.1021/acs.jmedchem.2c01195. Epub 2022 Oct 28. J Med Chem. 2022. PMID: 36306808 Free PMC article.
Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 Mpro Protease through Virtual Screening.
Rubio-Martínez J, Jiménez-Alesanco A, Ceballos-Laita L, Ortega-Alarcón D, Vega S, Calvo C, Benítez C, Abian O, Velázquez-Campoy A, Thomson TM, Granadino-Roldán JM, Gómez-Gutiérrez P, Pérez JJ. Rubio-Martínez J, et al. Among authors: ortega alarcon d. J Chem Inf Model. 2021 Dec 27;61(12):6094-6106. doi: 10.1021/acs.jcim.1c00951. Epub 2021 Nov 22. J Chem Inf Model. 2021. PMID: 34806382 Free PMC article.
Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.
López-Méndez B, Baron B, Brautigam CA, Jowitt TA, Knauer SH, Uebel S, Williams MA, Sedivy A, Abian O, Abreu C, Adamczyk M, Bal W, Berger S, Buell AK, Carolis C, Daviter T, Fish A, Garcia-Alai M, Guenther C, Hamacek J, Holková J, Houser J, Johnson C, Kelly S, Leech A, Mas C, Matulis D, McLaughlin SH, Montserret R, Nasreddine R, Nehmé R, Nguyen Q, Ortega-Alarcón D, Perez K, Pirc K, Piszczek G, Podobnik M, Rodrigo N, Rokov-Plavec J, Schaefer S, Sharpe T, Southall J, Staunton D, Tavares P, Vanek O, Weyand M, Wu D. López-Méndez B, et al. Among authors: ortega alarcon d. Eur Biophys J. 2021 Dec;50(8):1159-1160. doi: 10.1007/s00249-021-01573-x. Eur Biophys J. 2021. PMID: 34652497 Free PMC article. No abstract available.
l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells.
Sancineto L, Ostacolo C, Ortega-Alarcon D, Jimenez-Alesanco A, Ceballos-Laita L, Vega S, Abian O, Velazquez-Campoy A, Moretti S, Dabrowska A, Botwina P, Synowiec A, Kula-Pacurar A, Pyrc K, Iraci N, Santi C. Sancineto L, et al. Among authors: ortega alarcon d. Molecules. 2021 Oct 7;26(19):6062. doi: 10.3390/molecules26196062. Molecules. 2021. PMID: 34641606 Free PMC article.
Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds.
Rizzuti B, Ceballos-Laita L, Ortega-Alarcon D, Jimenez-Alesanco A, Vega S, Grande F, Conforti F, Abian O, Velazquez-Campoy A. Rizzuti B, et al. Among authors: ortega alarcon d. Pharmaceuticals (Basel). 2021 Sep 1;14(9):892. doi: 10.3390/ph14090892. Pharmaceuticals (Basel). 2021. PMID: 34577592 Free PMC article.
18 results