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Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer.
van de Haar J, Ma X, Ooft SN, van der Helm PW, Hoes LR, Mainardi S, Pinato DJ, Sun K, Salvatore L, Tortora G, Zurlo IV, Leo S, Giampieri R, Berardi R, Gelsomino F, Merz V, Mazzuca F, Antonuzzo L, Rosati G, Stavraka C, Ross P, Rodriquenz MG, Pavarana M, Messina C, Iveson T, Zoratto F, Thomas A, Fenocchio E, Ratti M, Depetris I, Cergnul M, Morelli C, Libertini M, Parisi A, De Tursi M, Zanaletti N, Garrone O, Graham J, Longarini R, Gobba SM, Petrillo A, Tamburini E, La Verde N, Petrelli F, Ricci V, Wessels LFA, Ghidini M, Cortellini A, Voest EE, Valeri N. van de Haar J, et al. Among authors: ooft sn. Nat Med. 2023 Mar;29(3):605-614. doi: 10.1038/s41591-023-02240-8. Epub 2023 Mar 2. Nat Med. 2023. PMID: 36864254 Free PMC article. Clinical Trial.
Prospective experimental treatment of colorectal cancer patients based on organoid drug responses.
Ooft SN, Weeber F, Schipper L, Dijkstra KK, McLean CM, Kaing S, van de Haar J, Prevoo W, van Werkhoven E, Snaebjornsson P, Hoes LR, Chalabi M, van der Velden D, van Leerdam M, Boot H, Grootscholten C, Huitema ADR, Bloemendal HJ, Cuppen E, Voest EE. Ooft SN, et al. ESMO Open. 2021 Jun;6(3):100103. doi: 10.1016/j.esmoop.2021.100103. Epub 2021 Apr 19. ESMO Open. 2021. PMID: 33887686 Free PMC article.
Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.
Fernandes Neto JM, Nadal E, Bosdriesz E, Ooft SN, Farre L, McLean C, Klarenbeek S, Jurgens A, Hagen H, Wang L, Felip E, Martinez-Marti A, Vidal A, Voest E, Wessels LFA, van Tellingen O, Villanueva A, Bernards R. Fernandes Neto JM, et al. Among authors: ooft sn. Nat Commun. 2020 Jun 22;11(1):3157. doi: 10.1038/s41467-020-16952-9. Nat Commun. 2020. PMID: 32572029 Free PMC article.
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.
Ooft SN, Weeber F, Dijkstra KK, McLean CM, Kaing S, van Werkhoven E, Schipper L, Hoes L, Vis DJ, van de Haar J, Prevoo W, Snaebjornsson P, van der Velden D, Klein M, Chalabi M, Boot H, van Leerdam M, Bloemendal HJ, Beerepoot LV, Wessels L, Cuppen E, Clevers H, Voest EE. Ooft SN, et al. Sci Transl Med. 2019 Oct 9;11(513):eaay2574. doi: 10.1126/scitranslmed.aay2574. Sci Transl Med. 2019. PMID: 31597751
Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.
Weeber F, Ooft SN, Dijkstra KK, Voest EE. Weeber F, et al. Among authors: ooft sn. Cell Chem Biol. 2017 Sep 21;24(9):1092-1100. doi: 10.1016/j.chembiol.2017.06.012. Epub 2017 Jul 27. Cell Chem Biol. 2017. PMID: 28757181 Free article. Review.