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A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS; Type 1 Diabetes Genetics Consortium. Concannon P, et al. Diabetes. 2008 Oct;57(10):2858-61. doi: 10.2337/db08-0753. Epub 2008 Jul 22. Diabetes. 2008. PMID: 18647951 Free PMC article.
Recent progress in the genetics of diabetes.
Rich SS, Onengut-Gumuscu S, Concannon P. Rich SS, et al. Horm Res. 2009 Jan;71 Suppl 1:17-23. doi: 10.1159/000178031. Epub 2009 Jan 21. Horm Res. 2009. PMID: 19153499
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; Type 1 Diabetes Genetics Consortium. Barrett JC, et al. Nat Genet. 2009 Jun;41(6):703-7. doi: 10.1038/ng.381. Epub 2009 May 10. Nat Genet. 2009. PMID: 19430480 Free PMC article.
Imputing amino acid polymorphisms in human leukocyte antigens.
Jia X, Han B, Onengut-Gumuscu S, Chen WM, Concannon PJ, Rich SS, Raychaudhuri S, de Bakker PI. Jia X, et al. PLoS One. 2013 Jun 6;8(6):e64683. doi: 10.1371/journal.pone.0064683. Print 2013. PLoS One. 2013. PMID: 23762245 Free PMC article.
HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.
Fernandez CA, Smith C, Yang W, Daté M, Bashford D, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Turner V, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. Fernandez CA, et al. Blood. 2014 Aug 21;124(8):1266-76. doi: 10.1182/blood-2014-03-563742. Epub 2014 Jun 26. Blood. 2014. PMID: 24970932 Free PMC article. Clinical Trial.
Risk of pediatric celiac disease according to HLA haplotype and country.
Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D; TEDDY Study Group. Liu E, et al. N Engl J Med. 2014 Jul 3;371(1):42-9. doi: 10.1056/NEJMoa1313977. N Engl J Med. 2014. PMID: 24988556 Free PMC article.
141 results