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Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.
Feng Z, Hom ME, Bearrood TE, Rosenthal ZC, Fernández D, Ondrus AE, Gu Y, McCormick AK, Tomaske MG, Marshall CR, Kline T, Chen CH, Mochly-Rosen D, Kuo CJ, Chen JK. Feng Z, et al. Among authors: ondrus ae. Nat Chem Biol. 2022 Oct;18(10):1065-1075. doi: 10.1038/s41589-022-01048-w. Epub 2022 Jul 4. Nat Chem Biol. 2022. PMID: 35788181 Free PMC article.
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Steinman JB, et al. Among authors: ondrus ae. Elife. 2017 May 19;6:e25174. doi: 10.7554/eLife.25174. Elife. 2017. PMID: 28524820 Free PMC article.
A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes.
Cheng YS, Zhang T, Ma X, Pratuangtham S, Zhang GC, Ondrus AA, Mafi A, Lomenick B, Jones JJ, Ondrus AE. Cheng YS, et al. Among authors: ondrus ae. Nat Chem Biol. 2021 Dec;17(12):1271-1280. doi: 10.1038/s41589-021-00907-2. Epub 2021 Nov 19. Nat Chem Biol. 2021. PMID: 34799735 Free PMC article.
Indolactam Dipeptides as Nanomolar Gli Inhibitors.
Mendoza M, Tran U, Zhang GC, Leister J, To K, Malepeai-Tofaeono T, Ondrus AE, Billingsley KL. Mendoza M, et al. Among authors: ondrus ae. ACS Med Chem Lett. 2022 Jun 3;13(7):1036-1042. doi: 10.1021/acsmedchemlett.1c00562. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859880 Free PMC article.
Hedgehog proteins create a dynamic cholesterol interface.
Mafi A, Purohit R, Vielmas E, Lauinger AR, Lam B, Cheng YS, Zhang T, Huang Y, Kim SK, Goddard WA 3rd, Ondrus AE. Mafi A, et al. Among authors: ondrus ae. PLoS One. 2021 Feb 25;16(2):e0246814. doi: 10.1371/journal.pone.0246814. eCollection 2021. PLoS One. 2021. PMID: 33630857 Free PMC article.
20 results