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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. No JH, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4058-63. doi: 10.1073/pnas.1118215109. Epub 2012 Mar 5. Proc Natl Acad Sci U S A. 2012. PMID: 22392982 Free PMC article.
Resistance-resistant antibiotics.
Oldfield E, Feng X. Oldfield E, et al. Trends Pharmacol Sci. 2014 Dec;35(12):664-74. doi: 10.1016/j.tips.2014.10.007. Epub 2014 Nov 5. Trends Pharmacol Sci. 2014. PMID: 25458541 Free PMC article. Review.
Antiinfectives targeting enzymes and the proton motive force.
Feng X, Zhu W, Schurig-Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T, Kim BK, Crick DC, Cynamon M, McCammon JA, Gennis RB, Oldfield E. Feng X, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7073-82. doi: 10.1073/pnas.1521988112. Epub 2015 Dec 7. Proc Natl Acad Sci U S A. 2015. PMID: 26644565 Free PMC article.
Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
Malwal SR, O'Dowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E. Malwal SR, et al. Among authors: oldfield e. J Am Chem Soc. 2018 Jun 20;140(24):7568-7578. doi: 10.1021/jacs.8b02363. Epub 2018 Jun 5. J Am Chem Soc. 2018. PMID: 29787268 Free PMC article.
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
Stampolaki M, Malwal SR, Alvarez-Cabrera N, Gao Z, Moniruzzaman M, Babii SO, Naziris N, Rey-Cibati A, Valladares-Delgado M, Turcu AL, Baek KH, Phan TN, Lee H, Alcaraz M, Watson S, van der Watt M, Coertzen D, Efstathiou N, Chountoulesi M, Shoen CM, Papanastasiou IP, Brea J, Cynamon MH, Birkholtz LM, Kremer L, No JH, Vázquez S, Benaim G, Demetzos C, Zgurskaya HI, Dick T, Oldfield E, Kolocouris AD. Stampolaki M, et al. Among authors: oldfield e. ACS Infect Dis. 2023 Feb 10;9(2):342-364. doi: 10.1021/acsinfecdis.2c00537. Epub 2023 Jan 27. ACS Infect Dis. 2023. PMID: 36706233 Free PMC article.
927 results