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Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
Rujas E, Insausti S, Leaman DP, Carravilla P, González-Resines S, Monceaux V, Sánchez-Eugenia R, García-Porras M, Iloro I, Zhang L, Elortza F, Julien JP, Saéz-Cirión A, Zwick MB, Eggeling C, Ojida A, Domene C, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: ojida a. Cell Rep. 2020 Aug 18;32(7):108037. doi: 10.1016/j.celrep.2020.108037. Cell Rep. 2020. PMID: 32814041 Free PMC article.
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.
Kaku T, Hitaka T, Ojida A, Matsunaga N, Adachi M, Tanaka T, Hara T, Yamaoka M, Kusaka M, Okuda T, Asahi S, Furuya S, Tasaka A. Kaku T, et al. Among authors: ojida a. Bioorg Med Chem. 2011 Nov 1;19(21):6383-99. doi: 10.1016/j.bmc.2011.08.066. Epub 2011 Sep 1. Bioorg Med Chem. 2011. PMID: 21978946
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A. Shindo N, et al. Among authors: ojida a. Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14. Nat Chem Biol. 2019. PMID: 30643284
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T, Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A. Hirose Y, et al. Among authors: ojida a. J Med Chem. 2022 Oct 27;65(20):13852-13865. doi: 10.1021/acs.jmedchem.2c01081. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36229406
90 results