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Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Iwai K, Nambu T, Dairiki R, Ohori M, Yu J, Burke K, Gotou M, Yamamoto Y, Ebara S, Shibata S, Hibino R, Nishizawa S, Miyazaki T, Homma M, Oguro Y, Imada T, Cho N, Uchiyama N, Kogame A, Takeuchi T, Kurasawa O, Yamanaka K, Niu H, Ohashi A. Iwai K, et al. Among authors: ohori m. Sci Adv. 2019 May 22;5(5):eaav3660. doi: 10.1126/sciadv.aav3660. eCollection 2019 May. Sci Adv. 2019. PMID: 31131319 Free PMC article.
Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
Hirayama T, Okaniwa M, Banno H, Kakei H, Ohashi A, Iwai K, Ohori M, Mori K, Gotou M, Kawamoto T, Yokota A, Ishikawa T. Hirayama T, et al. Among authors: ohori m. J Med Chem. 2015 Oct 22;58(20):8036-53. doi: 10.1021/acs.jmedchem.5b00836. Epub 2015 Oct 1. J Med Chem. 2015. PMID: 26372373
A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.
Ohashi A, Ohori M, Iwai K, Nambu T, Miyamoto M, Kawamoto T, Okaniwa M. Ohashi A, et al. Among authors: ohori m. PLoS One. 2015 Dec 9;10(12):e0144675. doi: 10.1371/journal.pone.0144675. eCollection 2015. PLoS One. 2015. PMID: 26649895 Free PMC article.
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S. Funnell T, et al. Among authors: ohori m. Nat Commun. 2017 Feb 23;8(1):7. doi: 10.1038/s41467-016-0008-7. Nat Commun. 2017. PMID: 28232751 Free PMC article.
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
Kurasawa O, Miyazaki T, Homma M, Oguro Y, Imada T, Uchiyama N, Iwai K, Yamamoto Y, Ohori M, Hara H, Sugimoto H, Iwata K, Skene R, Hoffman I, Ohashi A, Nomura T, Cho N. Kurasawa O, et al. Among authors: ohori m. J Med Chem. 2020 Feb 13;63(3):1084-1104. doi: 10.1021/acs.jmedchem.9b01427. Epub 2020 Jan 14. J Med Chem. 2020. PMID: 31895562
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Nakao S, Nogami M, Iwatani M, Imaeda T, Ito M, Tanaka T, Tawada M, Endo S, Cary DR, Ohori M, Imaeda Y, Kawamoto T, Aparicio S, Nakanishi A, Araki S. Nakao S, et al. Among authors: ohori m. Biochem Biophys Res Commun. 2020 Mar 12;523(3):795-801. doi: 10.1016/j.bbrc.2019.12.094. Epub 2020 Jan 15. Biochem Biophys Res Commun. 2020. PMID: 31954521 Free article.
200 results