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Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists.
Cirella A, Bolaños E, Luri-Rey C, Di Trani CA, Olivera I, Gomis G, Glez-Vaz J, Pinci B, Garasa S, Sánchez-Gregorio S, Azpilikueta A, Eguren-Santamaria I, Valencia K, Palencia B, Alvarez M, Ochoa MC, Teijeira Á, Berraondo P, Melero I. Cirella A, et al. Among authors: ochoa mc. Mol Ther Nucleic Acids. 2023 Jul 28;33:668-682. doi: 10.1016/j.omtn.2023.07.026. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37650116 Free PMC article.
In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.
Murillo O, Dubrot J, Palazón A, Arina A, Azpilikueta A, Alfaro C, Solano S, Ochoa MC, Berasain C, Gabari I, Pérez-Gracia JL, Berraondo P, Hervás-Stubbs S, Melero I. Murillo O, et al. Among authors: ochoa mc. Eur J Immunol. 2009 Sep;39(9):2424-36. doi: 10.1002/eji.200838958. Eur J Immunol. 2009. PMID: 19662633 Free article.
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Dubrot J, Milheiro F, Alfaro C, Palazón A, Martinez-Forero I, Perez-Gracia JL, Morales-Kastresana A, Romero-Trevejo JL, Ochoa MC, Hervás-Stubbs S, Prieto J, Jure-Kunkel M, Chen L, Melero I. Dubrot J, et al. Among authors: ochoa mc. Cancer Immunol Immunother. 2010 Aug;59(8):1223-33. doi: 10.1007/s00262-010-0846-9. Epub 2010 Mar 25. Cancer Immunol Immunother. 2010. PMID: 20336294 Free PMC article.
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.
Palazón A, Teijeira A, Martínez-Forero I, Hervás-Stubbs S, Roncal C, Peñuelas I, Dubrot J, Morales-Kastresana A, Pérez-Gracia JL, Ochoa MC, Ochoa-Callejero L, Martínez A, Luque A, Dinchuk J, Rouzaut A, Jure-Kunkel M, Melero I. Palazón A, et al. Among authors: ochoa callejero l, ochoa mc. Cancer Res. 2011 Feb 1;71(3):801-11. doi: 10.1158/0008-5472.CAN-10-1733. Epub 2011 Jan 25. Cancer Res. 2011. PMID: 21266358
Interleukin-15 in gene therapy of cancer.
Ochoa MC, Mazzolini G, Hervas-Stubbs S, de Sanmamed MF, Berraondo P, Melero I. Ochoa MC, et al. Curr Gene Ther. 2013 Feb;13(1):15-30. doi: 10.2174/156652313804806561. Curr Gene Ther. 2013. PMID: 23157547 Review.
71 results