Obermann W - Search Results

1

Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates.

Obermann W, Azri MFD, Konopka L, Schmidt N, Magari F, Sherman J, Silva LMR, Hermosilla C, Ludewig AH, Houhou H, Haeberlein S, Luo MY, Häcker I, Schetelig MF, Grevelding CG, Schroeder FC, Lau GSK, Taubert A, Rodriguez A, Heine A, Yeo TC, Grünweller A, Taroncher-Oldenburg G. Obermann W, et al. Sci Rep. 2023 Jun 8;13(1):9297. doi: 10.1038/s41598-023-35765-6. Sci Rep. 2023. PMID: 37291191 Free PMC article.

2

The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo.

Müller C, Obermann W, Karl N, Wendel HG, Taroncher-Oldenburg G, Pleschka S, Hartmann RK, Grünweller A, Ziebuhr J. Müller C, et al. Among authors: obermann w. Antiviral Res. 2021 Feb;186:105012. doi: 10.1016/j.antiviral.2021.105012. Epub 2021 Jan 8. Antiviral Res. 2021. PMID: 33422611 Free PMC article.

3

Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates-A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics.

Taroncher-Oldenburg G, Müller C, Obermann W, Ziebuhr J, Hartmann RK, Grünweller A. Taroncher-Oldenburg G, et al. Among authors: obermann w. Microorganisms. 2021 Mar 5;9(3):540. doi: 10.3390/microorganisms9030540. Microorganisms. 2021. PMID: 33807988 Free PMC article. Review.

4

Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol.

Müller C, Obermann W, Schulte FW, Lange-Grünweller K, Oestereich L, Elgner F, Glitscher M, Hildt E, Singh K, Wendel HG, Hartmann RK, Ziebuhr J, Grünweller A. Müller C, et al. Among authors: obermann w. Antiviral Res. 2020 Mar;175:104706. doi: 10.1016/j.antiviral.2020.104706. Epub 2020 Jan 10. Antiviral Res. 2020. PMID: 31931103 Free PMC article.

5

Synthesis and antischistosomal activity of linker- and thiophene-modified biaryl alkyl carboxylic acid derivatives.

Peter Ventura AM, Haeberlein S, Konopka L, Obermann W, Grünweller A, Grevelding CG, Schlitzer M. Peter Ventura AM, et al. Among authors: obermann w. Arch Pharm (Weinheim). 2021 Dec;354(12):e2100259. doi: 10.1002/ardp.202100259. Epub 2021 Sep 15. Arch Pharm (Weinheim). 2021. PMID: 34523746

6

From dithiocarbamates to branched dithiocarbazates: Compounds with potent antischistosomal activity.

Gallinger TL, Obermann W, Lange-Grünweller K, Schmidt N, Haeberlein S, Grünweller A, Grevelding CG, Schlitzer M. Gallinger TL, et al. Among authors: obermann w. Arch Pharm (Weinheim). 2023 Mar;356(3):e2200491. doi: 10.1002/ardp.202200491. Epub 2022 Dec 8. Arch Pharm (Weinheim). 2023. PMID: 36482264

7

First In Silico Screening of Insect Molecules for Identification of Novel Anti-Parasitic Compounds.

Gallinger TL, Aboagye SY, Obermann W, Weiss M, Grünweller A, Unverzagt C, Williams DL, Schlitzer M, Haeberlein S. Gallinger TL, et al. Among authors: obermann w. Pharmaceuticals (Basel). 2022 Jan 19;15(2):119. doi: 10.3390/ph15020119. Pharmaceuticals (Basel). 2022. PMID: 35215232 Free PMC article.

8

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity.

Obermann W, Friedrich A, Madhugiri R, Klemm P, Mengel JP, Hain T, Pleschka S, Wendel HG, Hartmann RK, Schiffmann S, Ziebuhr J, Müller C, Grünweller A. Obermann W, et al. Viruses. 2022 Mar 3;14(3):519. doi: 10.3390/v14030519. Viruses. 2022. PMID: 35336926 Free PMC article.

9

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses.

Müller C, Schulte FW, Lange-Grünweller K, Obermann W, Madhugiri R, Pleschka S, Ziebuhr J, Hartmann RK, Grünweller A. Müller C, et al. Among authors: obermann w. Antiviral Res. 2018 Feb;150:123-129. doi: 10.1016/j.antiviral.2017.12.010. Epub 2017 Dec 16. Antiviral Res. 2018. PMID: 29258862 Free PMC article.

10

Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.

Peiffer KH, Spengler C, Basic M, Jiang B, Kuhnhenn L, Obermann W, Zahn T, Glitscher M, Loglio A, Facchetti F, Carra G, Kubesch A, Vermehren J, Knop V, Graf C, Dietz J, Finkelmeier F, Herrmann E, Trebicka J, Grünweller A, Zeuzem S, Sarrazin C, Lampertico P, Hildt E. Peiffer KH, et al. Among authors: obermann w. JCI Insight. 2020 Nov 19;5(22):e135833. doi: 10.1172/jci.insight.135833. JCI Insight. 2020. PMID: 33055418 Free PMC article.

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