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Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life.
Uhlmann RE, Rother C, Rasmussen J, Schelle J, Bergmann C, Ullrich Gavilanes EM, Fritschi SK, Buehler A, Baumann F, Skodras A, Al-Shaana R, Beschorner N, Ye L, Kaeser SA, Obermüller U, Christensen S, Kartberg F, Stavenhagen JB, Rahfeld JU, Cynis H, Qian F, Weinreb PH, Bussiere T, Walker LC, Staufenbiel M, Jucker M. Uhlmann RE, et al. Among authors: obermuller u. Nat Neurosci. 2020 Dec;23(12):1580-1588. doi: 10.1038/s41593-020-00737-w. Epub 2020 Nov 16. Nat Neurosci. 2020. PMID: 33199898 Free PMC article.
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
Eisele YS, Obermüller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M. Eisele YS, et al. Among authors: obermuller u. Science. 2010 Nov 12;330(6006):980-2. doi: 10.1126/science.1194516. Epub 2010 Oct 21. Science. 2010. PMID: 20966215 Free PMC article.
Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.
Eisele YS, Fritschi SK, Hamaguchi T, Obermüller U, Füger P, Skodras A, Schäfer C, Odenthal J, Heikenwalder M, Staufenbiel M, Jucker M. Eisele YS, et al. Among authors: obermuller u. J Neurosci. 2014 Jul 30;34(31):10264-73. doi: 10.1523/JNEUROSCI.1608-14.2014. J Neurosci. 2014. PMID: 25080588 Free PMC article.
Persistence of Aβ seeds in APP null mouse brain.
Ye L, Fritschi SK, Schelle J, Obermüller U, Degenhardt K, Kaeser SA, Eisele YS, Walker LC, Baumann F, Staufenbiel M, Jucker M. Ye L, et al. Among authors: obermuller u. Nat Neurosci. 2015 Nov;18(11):1559-61. doi: 10.1038/nn.4117. Epub 2015 Sep 9. Nat Neurosci. 2015. PMID: 26352792
Highly potent intracellular membrane-associated Aβ seeds.
Marzesco AM, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, Baumann F. Marzesco AM, et al. Among authors: obermuller u. Sci Rep. 2016 Jun 17;6:28125. doi: 10.1038/srep28125. Sci Rep. 2016. PMID: 27311744 Free PMC article.
Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.
Ye L, Rasmussen J, Kaeser SA, Marzesco AM, Obermüller U, Mahler J, Schelle J, Odenthal J, Krüger C, Fritschi SK, Walker LC, Staufenbiel M, Baumann F, Jucker M. Ye L, et al. Among authors: obermuller u. EMBO Rep. 2017 Sep;18(9):1536-1544. doi: 10.15252/embr.201744067. Epub 2017 Jul 12. EMBO Rep. 2017. PMID: 28701326 Free PMC article.
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.
Tanriöver G, Bacioglu M, Schweighauser M, Mahler J, Wegenast-Braun BM, Skodras A, Obermüller U, Barth M, Kronenberg-Versteeg D, Nilsson KPR, Shimshek DR, Kahle PJ, Eisele YS, Jucker M. Tanriöver G, et al. Among authors: obermuller u. Acta Neuropathol Commun. 2020 Aug 12;8(1):133. doi: 10.1186/s40478-020-00993-8. Acta Neuropathol Commun. 2020. PMID: 32787922 Free PMC article.
23 results