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Page 1
Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function.
Blazev R, Carl CS, Ng YK, Molendijk J, Voldstedlund CT, Zhao Y, Xiao D, Kueh AJ, Miotto PM, Haynes VR, Hardee JP, Chung JD, McNamara JW, Qian H, Gregorevic P, Oakhill JS, Herold MJ, Jensen TE, Lisowski L, Lynch GS, Dodd GT, Watt MJ, Yang P, Kiens B, Richter EA, Parker BL. Blazev R, et al. Among authors: oakhill js. Cell Metab. 2022 Oct 4;34(10):1561-1577.e9. doi: 10.1016/j.cmet.2022.07.003. Epub 2022 Jul 25. Cell Metab. 2022. PMID: 35882232 Free article.
SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
Wells C, Liang Y, Pulliam TL, Lin C, Awad D, Eduful B, O'Byrne S, Hossain MA, Catta-Preta CMC, Ramos PZ, Gileadi O, Gileadi C, Couñago RM, Stork B, Langendorf CG, Nay K, Oakhill JS, Mukherjee D, Racioppi L, Means AR, York B, McDonnell DP, Scott JW, Frigo DE, Drewry DH. Wells C, et al. Among authors: oakhill js. Cells. 2023 Jan 11;12(2):287. doi: 10.3390/cells12020287. Cells. 2023. PMID: 36672221 Free PMC article.
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.
Dzamko N, Schertzer JD, Ryall JG, Steel R, Macaulay SL, Wee S, Chen ZP, Michell BJ, Oakhill JS, Watt MJ, Jørgensen SB, Lynch GS, Kemp BE, Steinberg GR. Dzamko N, et al. Among authors: oakhill js. J Physiol. 2008 Dec 1;586(23):5819-31. doi: 10.1113/jphysiol.2008.159814. Epub 2008 Oct 9. J Physiol. 2008. PMID: 18845612 Free PMC article.
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.
Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: oakhill js. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.
Ngoei KRW, Langendorf CG, Ling NXY, Hoque A, Varghese S, Camerino MA, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB, Oakhill JS. Ngoei KRW, et al. Among authors: oakhill js. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. doi: 10.1016/j.chembiol.2018.03.008. Epub 2018 Apr 12. Cell Chem Biol. 2018. PMID: 29657085 Free article.
Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.
Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE. Nelson ME, et al. Among authors: oakhill js. EMBO J. 2019 Dec 16;38(24):e102578. doi: 10.15252/embj.2019102578. Epub 2019 Aug 5. EMBO J. 2019. PMID: 31381180 Free PMC article.
Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.
Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE. Nelson ME, et al. Among authors: oakhill js. EMBO J. 2020 Apr 15;39(8):e104246. doi: 10.15252/embj.2019104246. EMBO J. 2020. PMID: 32291792 Free PMC article. No abstract available.
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism.
Hoffman NJ, Whitfield J, Janzen NR, Belhaj MR, Galic S, Murray-Segal L, Smiles WJ, Ling NXY, Dite TA, Scott JW, Oakhill JS, Brink R, Kemp BE, Hawley JA. Hoffman NJ, et al. Among authors: oakhill js. Mol Metab. 2020 Nov;41:101048. doi: 10.1016/j.molmet.2020.101048. Epub 2020 Jun 29. Mol Metab. 2020. PMID: 32610071 Free PMC article.
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle.
Rhein P, Desjardins EM, Rong P, Ahwazi D, Bonhoure N, Stolte J, Santos MD, Ovens AJ, Ehrlich AM, Sanchez Garcia JL, Ouyang Q, Yabut JM, Kjolby M, Membrez M, Jessen N, Oakhill JS, Treebak JT, Maire P, Scott JW, Sanders MJ, Descombes P, Chen S, Steinberg GR, Sakamoto K. Rhein P, et al. Among authors: oakhill js. Mol Metab. 2021 Sep;51:101228. doi: 10.1016/j.molmet.2021.101228. Epub 2021 Mar 30. Mol Metab. 2021. PMID: 33798773 Free PMC article.
Personalized phosphoproteomics identifies functional signaling.
Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Needham EJ, et al. Among authors: oakhill js. Nat Biotechnol. 2022 Apr;40(4):576-584. doi: 10.1038/s41587-021-01099-9. Epub 2021 Dec 2. Nat Biotechnol. 2022. PMID: 34857927
80 results