O'Mahony A - Search Results

1

Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.

Haselmayer P, Camps M, Liu-Bujalski L, Nguyen N, Morandi F, Head J, O'Mahony A, Zimmerli SC, Bruns L, Bender AT, Schroeder P, Grenningloh R. Haselmayer P, et al. J Immunol. 2019 May 15;202(10):2888-2906. doi: 10.4049/jimmunol.1800583. Epub 2019 Apr 15. J Immunol. 2019. PMID: 30988116 Free PMC article.

2

Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.

O'Mahony A, John MR, Cho H, Hashizume M, Choy EH. O'Mahony A, et al. J Transl Med. 2018 Jun 7;16(1):156. doi: 10.1186/s12967-018-1532-5. J Transl Med. 2018. PMID: 29879987 Free PMC article.

3

RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.

Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, O'Mahony A, Owens TD, Lou Y, Hill RJ, Narula S, DeMartino J, Fine JS. Xu D, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. doi: 10.1124/jpet.111.187740. Epub 2012 Jan 6. J Pharmacol Exp Ther. 2012. PMID: 22228807

4

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation.

Melton AC, Melrose J, Alajoki L, Privat S, Cho H, Brown N, Plavec AM, Nguyen D, Johnston ED, Yang J, Polokoff MA, Plavec I, Berg EL, O'Mahony A. Melton AC, et al. PLoS One. 2013;8(3):e58966. doi: 10.1371/journal.pone.0058966. Epub 2013 Mar 7. PLoS One. 2013. PMID: 23505568 Free PMC article.

5

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Hammitzsch A, Tallant C, Fedorov O, O'Mahony A, Brennan PE, Hay DA, Martinez FO, Al-Mossawi MH, de Wit J, Vecellio M, Wells C, Wordsworth P, Müller S, Knapp S, Bowness P. Hammitzsch A, et al. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10768-73. doi: 10.1073/pnas.1501956112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261308 Free PMC article.

6

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

Bergamini G, Bell K, Shimamura S, Werner T, Cansfield A, Müller K, Perrin J, Rau C, Ellard K, Hopf C, Doce C, Leggate D, Mangano R, Mathieson T, O'Mahony A, Plavec I, Rharbaoui F, Reinhard F, Savitski MM, Ramsden N, Hirsch E, Drewes G, Rausch O, Bantscheff M, Neubauer G. Bergamini G, et al. Nat Chem Biol. 2012 Apr 29;8(6):576-82. doi: 10.1038/nchembio.957. Nat Chem Biol. 2012. PMID: 22544264

7

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.

Shah F, Stepan AF, O'Mahony A, Velichko S, Folias AE, Houle C, Shaffer CL, Marcek J, Whritenour J, Stanton R, Berg EL. Shah F, et al. Cell Chem Biol. 2017 Jul 20;24(7):858-869.e5. doi: 10.1016/j.chembiol.2017.06.003. Epub 2017 Jun 29. Cell Chem Biol. 2017. PMID: 28669525 Free article.

8

Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

Berg EL, Polokoff MA, O'Mahony A, Nguyen D, Li X. Berg EL, et al. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008. Int J Mol Sci. 2015. PMID: 25569083 Free PMC article.

9

Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.

Singer JW, Al-Fayoumi S, Taylor J, Velichko S, O'Mahony A. Singer JW, et al. PLoS One. 2019 Sep 27;14(9):e0222944. doi: 10.1371/journal.pone.0222944. eCollection 2019. PLoS One. 2019. PMID: 31560729 Free PMC article.

10

[No title available]

[No authors listed] [No authors listed] PMID: 31963006

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