O'Keefe BR - Search Results

1

Photochemical Dimerization of Plakinidine B Leads to Potent Inhibition of the E3 Ubiquitin-Protein Ligase CBL-B.

Khong QT, Li D, Wilson BAP, Ranguelova K, Dalilian M, Smith EA, Wamiru A, Goncharova EI, Grkovic T, Voeller D, Lipkowitz S, Schnermann MJ, O'Keefe BR, Du L. Khong QT, et al. Org Lett. 2022 Dec 30;24(51):9468-9472. doi: 10.1021/acs.orglett.2c03922. Epub 2022 Dec 14. Org Lett. 2022. PMID: 36516994 Free PMC article.

2

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.

Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB. Takada K, et al. J Nat Prod. 2007 Oct;70(10):1647-9. doi: 10.1021/np0702279. Epub 2007 Oct 13. J Nat Prod. 2007. PMID: 17935297

3

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.

Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Sasiela CA, et al. J Biomol Screen. 2008 Mar;13(3):229-37. doi: 10.1177/1087057108315038. Epub 2008 Feb 12. J Biomol Screen. 2008. PMID: 18270365

4

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR. Wilson BA, et al. J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4. J Biomol Screen. 2016. PMID: 26538432 Free PMC article.

5

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1).

Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR. Bermingham A, et al. SLAS Discov. 2017 Oct;22(9):1093-1105. doi: 10.1177/2472555217717200. Epub 2017 Jul 11. SLAS Discov. 2017. PMID: 28697309 Free PMC article.

6

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Tsurumi F, et al. Org Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6. Org Lett. 2018. PMID: 29624062 Free PMC article.

7

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR. Thornburg CC, et al. ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13. ACS Chem Biol. 2018. PMID: 29812901 Free PMC article.

8

Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta.

Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR. Singh AJ, et al. J Nat Prod. 2018 Dec 28;81(12):2750-2755. doi: 10.1021/acs.jnatprod.8b00761. Epub 2018 Nov 29. J Nat Prod. 2018. PMID: 30495954 Free PMC article.

9

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR. Grkovic T, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10. Bioorg Med Chem Lett. 2019. PMID: 30553734 Free PMC article.

10

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Tran TD, et al. J Nat Prod. 2019 Jan 25;82(1):154-162. doi: 10.1021/acs.jnatprod.8b00871. Epub 2019 Jan 2. J Nat Prod. 2019. PMID: 30600998 Free PMC article.

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