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Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.
Nim S, O'Hara DM, Corbi-Verge C, Perez-Riba A, Fujisawa K, Kapadia M, Chau H, Albanese F, Pawar G, De Snoo ML, Ngana SG, Kim J, El-Agnaf OMA, Rennella E, Kay LE, Kalia SK, Kalia LV, Kim PM. Nim S, et al. Among authors: o hara dm. Nat Commun. 2023 Apr 19;14(1):2150. doi: 10.1038/s41467-023-37464-2. Nat Commun. 2023. PMID: 37076542 Free PMC article.
Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death.
De Snoo ML, Friesen EL, Zhang YT, Earnshaw R, Dorval G, Kapadia M, O'Hara DM, Agapova V, Chau H, Pellerito O, Tang MY, Wang X, Schmitt-Ulms G, Durcan TM, Fon EA, Kalia LV, Kalia SK. De Snoo ML, et al. Among authors: o hara dm. Cell Death Dis. 2019 Dec 2;10(12):907. doi: 10.1038/s41419-019-2132-x. Cell Death Dis. 2019. PMID: 31787745 Free PMC article.
Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans.
Chen KS, Menezes K, Rodgers JB, O'Hara DM, Tran N, Fujisawa K, Ishikura S, Khodaei S, Chau H, Cranston A, Kapadia M, Pawar G, Ping S, Krizus A, Lacoste A, Spangler S, Visanji NP, Marras C, Majbour NK, El-Agnaf OMA, Lozano AM, Culotti J, Suo S, Ryu WS, Kalia SK, Kalia LV. Chen KS, et al. Among authors: o hara dm. Mol Neurodegener. 2021 Nov 12;16(1):77. doi: 10.1186/s13024-021-00497-6. Mol Neurodegener. 2021. PMID: 34772429 Free PMC article.
38 results