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Exercise and the treatment of diabetes and obesity.
O'Gorman DJ, Krook A. O'Gorman DJ, et al. Endocrinol Metab Clin North Am. 2008 Dec;37(4):887-903. doi: 10.1016/j.ecl.2008.07.006. Endocrinol Metab Clin North Am. 2008. PMID: 19026938 Review.
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism.
Hernández-Alvarez MI, Díaz-Ramos A, Berdasco M, Cobb J, Planet E, Cooper D, Pazderska A, Wanic K, O'Hanlon D, Gomez A, de la Ballina LR, Esteller M, Palacin M, O'Gorman DJ, Nolan JJ, Zorzano A. Hernández-Alvarez MI, et al. Sci Rep. 2017 Oct 23;7(1):13850. doi: 10.1038/s41598-017-14120-6. Sci Rep. 2017. PMID: 29062026 Free PMC article.
Growth and differentiation factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans.
Laurens C, Parmar A, Murphy E, Carper D, Lair B, Maes P, Vion J, Boulet N, Fontaine C, Marquès M, Larrouy D, Harant I, Thalamas C, Montastier E, Caspar-Bauguil S, Bourlier V, Tavernier G, Grolleau JL, Bouloumié A, Langin D, Viguerie N, Bertile F, Blanc S, de Glisezinski I, O'Gorman D, Moro C. Laurens C, et al. JCI Insight. 2020 Mar 26;5(6):e131870. doi: 10.1172/jci.insight.131870. JCI Insight. 2020. PMID: 32106110 Free PMC article. Clinical Trial.
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