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Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease.
Pan Z, El Sharkway R, Bayoumi A, Metwally M, Gloss BS, Brink R, Lu DB, Liddle C, Alqahtani SA, Yu J, O'Connell PJ, George J, Eslam M. Pan Z, et al. Among authors: o connell pj. Sci Transl Med. 2024 Apr 3;16(741):eadj0133. doi: 10.1126/scitranslmed.adj0133. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569018
Intragraft memory-like CD127hiCD4+Foxp3+ Tregs maintain transplant tolerance.
Zhao Y, Nicholson L, Wang H, Qian YW, Hawthorne WJ, Jimenez-Vera E, Gloss BS, Lai J, Thomas A, Chew YV, Burns H, Zhang GY, Wang YM, Rogers NM, Zheng G, Yi S, Alexander SI, O'Connell PJ, Hu M. Zhao Y, et al. Among authors: o connell pj. JCI Insight. 2024 Feb 13;9(6):e169119. doi: 10.1172/jci.insight.169119. JCI Insight. 2024. PMID: 38516885 Free PMC article.
Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection.
Bestard O, Augustine J, Wee A, Poggio E, Mannon RB, Ansari MJ, Bhati C, Maluf D, Benken S, Leca N, La Manna G, Samaniego-Picota M, Shawar S, Concepcion BP, Rostaing L, Alberici F, O'Connell P, Chang A, Salem F, Kattan MW, Gallon L, Donovan MJ. Bestard O, et al. Among authors: o connell p. Am J Transplant. 2024 Mar;24(3):436-447. doi: 10.1016/j.ajt.2023.09.021. Epub 2023 Dec 7. Am J Transplant. 2024. PMID: 38152017 Free article.
A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization.
Yi Z, Xi C, Menon MC, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu EU, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin RB, Ward S, Salem F, Zhang W. Yi Z, et al. Among authors: o connell p. Kidney Int. 2024 Feb;105(2):281-292. doi: 10.1016/j.kint.2023.09.031. Epub 2023 Nov 3. Kidney Int. 2024. PMID: 37923131
1,006 results