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Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity.
Rosás-Umbert M, Gunst JD, Pahus MH, Olesen R, Schleimann M, Denton PW, Ramos V, Ward A, Kinloch NN, Copertino DC, Escribà T, Llano A, Brumme ZL, Brad Jones R, Mothe B, Brander C, Fox J, Nussenzweig MC, Fidler S, Caskey M, Tolstrup M, Søgaard OS. Rosás-Umbert M, et al. Among authors: nussenzweig mc. Nat Commun. 2022 Oct 29;13(1):6473. doi: 10.1038/s41467-022-34171-2. Nat Commun. 2022. PMID: 36309514 Free PMC article.
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.
Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC. Scheid JF, et al. Among authors: nussenzweig mc. Nature. 2009 Apr 2;458(7238):636-40. doi: 10.1038/nature07930. Epub 2009 Mar 15. Nature. 2009. PMID: 19287373
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Mouquet H, et al. Among authors: nussenzweig mc. Nature. 2010 Sep 30;467(7315):591-5. doi: 10.1038/nature09385. Nature. 2010. PMID: 20882016 Free PMC article.
A mouse model for HIV-1 entry.
Pietzsch J, Gruell H, Bournazos S, Donovan BM, Klein F, Diskin R, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. Pietzsch J, et al. Among authors: nussenzweig mc. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15859-64. doi: 10.1073/pnas.1213409109. Epub 2012 Sep 10. Proc Natl Acad Sci U S A. 2012. PMID: 23019371 Free PMC article.
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio P, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC. Klein F, et al. Among authors: nussenzweig mc. Nature. 2012 Dec 6;492(7427):118-22. doi: 10.1038/nature11604. Epub 2012 Oct 24. Nature. 2012. PMID: 23103874 Free PMC article.
Antibodies in HIV-1 vaccine development and therapy.
Klein F, Mouquet H, Dosenovic P, Scheid JF, Scharf L, Nussenzweig MC. Klein F, et al. Among authors: nussenzweig mc. Science. 2013 Sep 13;341(6151):1199-204. doi: 10.1126/science.1241144. Science. 2013. PMID: 24031012 Free PMC article. Review.
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.
Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Büning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC. Horwitz JA, et al. Among authors: nussenzweig mc. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16538-43. doi: 10.1073/pnas.1315295110. Epub 2013 Sep 16. Proc Natl Acad Sci U S A. 2013. PMID: 24043801 Free PMC article.
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. Barouch DH, et al. Among authors: nussenzweig mc. Nature. 2013 Nov 14;503(7475):224-8. doi: 10.1038/nature12744. Epub 2013 Oct 30. Nature. 2013. PMID: 24172905 Free PMC article.
468 results