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Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment.
Montane J, de Pablo S, Castaño C, Rodríguez-Comas J, Cadavez L, Obach M, Visa M, Alcarraz-Vizán G, Sanchez-Martinez M, Nonell-Canals A, Parrizas M, Servitja JM, Novials A. Montane J, et al. Among authors: novials a. FASEB J. 2017 Dec;31(12):5296-5306. doi: 10.1096/fj.201700236R. Epub 2017 Aug 15. FASEB J. 2017. PMID: 28821639 Free PMC article.
Collectively, these results uncover a novel beneficial effect of PBA on glucose homeostasis by restoring beta-cell function and preventing amyloid formation in mice expressing hIAPP in beta cells, highlighting the therapeutic potential of PBA for the treatment of T2D.-Mont …
Collectively, these results uncover a novel beneficial effect of PBA on glucose homeostasis by restoring beta-cell function and preve …
BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells.
Casas S, Casini P, Piquer S, Altirriba J, Soty M, Cadavez L, Gomis R, Novials A. Casas S, et al. Among authors: novials a. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1087-95. doi: 10.1152/ajpendo.00420.2010. Epub 2010 Oct 13. Am J Physiol Endocrinol Metab. 2010. PMID: 20943756 Free article.
Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state.
Moreno P, Acitores A, Gutiérrez-Rojas I, Nuche-Berenguer B, El Assar M, Rodriguez-Mañas L, Gomis R, Valverde I, Visa M, Malaisse WJ, Novials A, González N, Villanueva-Peñacarrillo ML. Moreno P, et al. Among authors: novials a. Peptides. 2011 Oct;32(10):2077-85. doi: 10.1016/j.peptides.2011.09.007. Epub 2011 Sep 16. Peptides. 2011. PMID: 21939703
110 results