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Page 1
Discovery of XL413, a potent and selective CDC7 inhibitor.
Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC. Koltun ES, et al. Among authors: noson k. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. doi: 10.1016/j.bmcl.2012.04.024. Epub 2012 Apr 16. Bioorg Med Chem Lett. 2012. PMID: 22560567
Discovery of a new class of glucosylceramide synthase inhibitors.
Koltun E, Richards S, Chan V, Nachtigall J, Du H, Noson K, Galan A, Aay N, Hanel A, Harrison A, Zhang J, Won KA, Tam D, Qian F, Wang T, Finn P, Ogilvie K, Rosen J, Mohan R, Larson C, Lamb P, Nuss J, Kearney P. Koltun E, et al. Among authors: noson k. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6773-7. doi: 10.1016/j.bmcl.2011.09.037. Epub 2011 Sep 17. Bioorg Med Chem Lett. 2011. PMID: 21974949
Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.
Leahy JW, Buhr CA, Johnson HW, Kim BG, Baik T, Cannoy J, Forsyth TP, Jeong JW, Lee MS, Ma S, Noson K, Wang L, Williams M, Nuss JM, Brooks E, Foster P, Goon L, Heald N, Holst C, Jaeger C, Lam S, Lougheed J, Nguyen L, Plonowski A, Song J, Stout T, Wu X, Yakes MF, Yu P, Zhang W, Lamb P, Raeber O. Leahy JW, et al. Among authors: noson k. J Med Chem. 2012 Jun 14;55(11):5467-82. doi: 10.1021/jm300403a. Epub 2012 May 17. J Med Chem. 2012. PMID: 22548342
Discovery of novel sphingosine kinase 1 inhibitors.
Xiang Y, Asmussen G, Booker M, Hirth B, Kane JL Jr, Liao J, Noson KD, Yee C. Xiang Y, et al. Among authors: noson kd. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21. doi: 10.1016/j.bmcl.2009.09.022. Epub 2009 Sep 10. Bioorg Med Chem Lett. 2009. PMID: 19800228
Discovery of novel sphingosine kinase-1 inhibitors. Part 2.
Xiang Y, Hirth B, Kane JL Jr, Liao J, Noson KD, Yee C, Asmussen G, Fitzgerald M, Klaus C, Booker M. Xiang Y, et al. Among authors: noson kd. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4. doi: 10.1016/j.bmcl.2010.06.019. Epub 2010 Jun 17. Bioorg Med Chem Lett. 2010. PMID: 20598880
A robust platform for the synthesis of new tetracycline antibiotics.
Sun C, Wang Q, Brubaker JD, Wright PM, Lerner CD, Noson K, Charest M, Siegel DR, Wang YM, Myers AG. Sun C, et al. Among authors: noson k. J Am Chem Soc. 2008 Dec 31;130(52):17913-27. doi: 10.1021/ja806629e. J Am Chem Soc. 2008. PMID: 19053822 Free PMC article.