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Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Hiatt JB, Sandborg H, Garrison SM, Arnold HU, Liao SY, Norton JP, Friesen TJ, Wu F, Sutherland KD, Rienhoff HY, Martins R, Houghton AM, Srivastava S, MacPherson D. Hiatt JB, et al. Among authors: norton jp. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. doi: 10.1158/1078-0432.CCR-22-1128. Clin Cancer Res. 2022. PMID: 35920742 Free PMC article.
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity.
Grunblatt E, Wu N, Zhang H, Liu X, Norton JP, Ohol Y, Leger P, Hiatt JB, Eastwood EC, Thomas R, Ibrahim AH, Jia D, Basom R, Eaton KD, Martins R, Houghton AM, MacPherson D. Grunblatt E, et al. Among authors: norton jp. Genes Dev. 2020 Sep 1;34(17-18):1210-1226. doi: 10.1101/gad.340133.120. Epub 2020 Aug 20. Genes Dev. 2020. PMID: 32820040 Free PMC article.
A conserved role for atlastin GTPases in regulating lipid droplet size.
Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV Jr, Blackstone C, Guo Y, Mak HY. Klemm RW, et al. Among authors: norton jp. Cell Rep. 2013 May 30;3(5):1465-75. doi: 10.1016/j.celrep.2013.04.015. Epub 2013 May 16. Cell Rep. 2013. PMID: 23684613 Free PMC article.
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