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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Nordström E, Eriksson F, Sigvardson J, Johannesson M, Kasrayan A, Jones-Kostalla M, Appelkvist P, Söderberg L, Nygren P, Blom M, Rachalski A, Nordenankar K, Zachrisson O, Amandius E, Osswald G, Moge M, Ingelsson M, Bergström J, Lannfelt L, Möller C, Giorgetti M, Fälting J. Nordström E, et al. Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1. Neurobiol Dis. 2021. PMID: 34737044 Free article.
Antibodies against alpha-synuclein reduce oligomerization in living cells.
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M. Näsström T, et al. Among authors: nordstrom e. PLoS One. 2011;6(10):e27230. doi: 10.1371/journal.pone.0027230. Epub 2011 Oct 31. PLoS One. 2011. PMID: 22073131 Free PMC article.
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.
Fagerqvist T, Lindström V, Nordström E, Lord A, Tucker SM, Su X, Sahlin C, Kasrayan A, Andersson J, Welander H, Näsström T, Holmquist M, Schell H, Kahle PJ, Kalimo H, Möller C, Gellerfors P, Lannfelt L, Bergström J, Ingelsson M. Fagerqvist T, et al. Among authors: nordstrom e. J Neurochem. 2013 Jul;126(1):131-44. doi: 10.1111/jnc.12175. Epub 2013 Feb 27. J Neurochem. 2013. PMID: 23363402 Free article.
Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice.
Lindström V, Fagerqvist T, Nordström E, Eriksson F, Lord A, Tucker S, Andersson J, Johannesson M, Schell H, Kahle PJ, Möller C, Gellerfors P, Bergström J, Lannfelt L, Ingelsson M. Lindström V, et al. Among authors: nordstrom e. Neurobiol Dis. 2014 Sep;69:134-43. doi: 10.1016/j.nbd.2014.05.009. Epub 2014 May 20. Neurobiol Dis. 2014. PMID: 24851801
Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils.
Ekmark-Lewén S, Aniszewska A, Molisak A, Gumucio A, Lindström V, Kahle PJ, Nordström E, Möller C, Fälting J, Lannfelt L, Bergström J, Ingelsson M. Ekmark-Lewén S, et al. Among authors: nordstrom e. Aging Brain. 2023 Jul 30;4:100086. doi: 10.1016/j.nbas.2023.100086. eCollection 2023. Aging Brain. 2023. PMID: 37559953 Free PMC article.
97 results