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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Raffel S, et al. Among authors: nonnenmacher y. Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8. Nature. 2017. PMID: 29144447
Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Raffel S, et al. Among authors: nonnenmacher y. Nature. 2018 Aug;560(7718):E28. doi: 10.1038/s41586-018-0403-9. Nature. 2018. PMID: 30069041
Biochemistry of proinflammatory macrophage activation.
Nonnenmacher Y, Hiller K. Nonnenmacher Y, et al. Cell Mol Life Sci. 2018 Jun;75(12):2093-2109. doi: 10.1007/s00018-018-2784-1. Epub 2018 Mar 3. Cell Mol Life Sci. 2018. PMID: 29502308 Free PMC article. Review.
Determining Compartment-Specific Metabolic Fluxes.
Nonnenmacher Y, Palorini R, Hiller K. Nonnenmacher Y, et al. Methods Mol Biol. 2019;1862:137-149. doi: 10.1007/978-1-4939-8769-6_10. Methods Mol Biol. 2019. PMID: 30315465
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production.
Ullmann P, Qureshi-Baig K, Rodriguez F, Ginolhac A, Nonnenmacher Y, Ternes D, Weiler J, Gäbler K, Bahlawane C, Hiller K, Haan S, Letellier E. Ullmann P, et al. Among authors: nonnenmacher y. Oncotarget. 2016 Oct 4;7(40):65454-65470. doi: 10.18632/oncotarget.11772. Oncotarget. 2016. PMID: 27589845 Free PMC article.
Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2.
Heinz A, Nonnenmacher Y, Henne A, Khalil MA, Bejkollari K, Dostert C, Hosseini S, Goldmann O, He W, Palorini R, Verschueren C, Korte M, Chiaradonna F, Medina E, Brenner D, Hiller K. Heinz A, et al. Among authors: nonnenmacher y. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166530. doi: 10.1016/j.bbadis.2022.166530. Epub 2022 Aug 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 36038039 Free article.
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: nonnenmacher y. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
Glutathione Primes T Cell Metabolism for Inflammation.
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Mak TW, et al. Among authors: nonnenmacher y. Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Immunity. 2017. PMID: 28423341 Free article.
16 results