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Improving T Cell Receptor On-Target Specificity via Structure-Guided Design.
Hellman LM, Foley KC, Singh NK, Alonso JA, Riley TP, Devlin JR, Ayres CM, Keller GLJ, Zhang Y, Vander Kooi CW, Nishimura MI, Baker BM. Hellman LM, et al. Among authors: nishimura mi. Mol Ther. 2019 Feb 6;27(2):300-313. doi: 10.1016/j.ymthe.2018.12.010. Epub 2018 Dec 14. Mol Ther. 2019. PMID: 30617019 Free PMC article.
TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors.
Spear TT, Callender GG, Roszkowski JJ, Moxley KM, Simms PE, Foley KC, Murray DC, Scurti GM, Li M, Thomas JT, Langerman A, Garrett-Mayer E, Zhang Y, Nishimura MI. Spear TT, et al. Among authors: nishimura mi. Cancer Immunol Immunother. 2016 Mar;65(3):293-304. doi: 10.1007/s00262-016-1800-2. Epub 2016 Feb 3. Cancer Immunol Immunother. 2016. PMID: 26842125 Free PMC article.
Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.
Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI. Spear TT, et al. Among authors: nishimura mi. J Leukoc Biol. 2016 Sep;100(3):545-57. doi: 10.1189/jlb.2A1215-561R. Epub 2016 Feb 26. J Leukoc Biol. 2016. PMID: 26921345 Free PMC article.
How an alloreactive T-cell receptor achieves peptide and MHC specificity.
Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM. Wang Y, et al. Among authors: nishimura mi. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. doi: 10.1073/pnas.1700459114. Epub 2017 Jun 1. Proc Natl Acad Sci U S A. 2017. PMID: 28572406 Free PMC article.
131 results