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eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T. Kashiwagi K, et al. Among authors: nishimoto m. Nat Commun. 2021 Dec 7;12(1):7102. doi: 10.1038/s41467-021-27337-x. Nat Commun. 2021. PMID: 34876589 Free PMC article.
Crystal structure of eukaryotic translation initiation factor 2B.
Kashiwagi K, Takahashi M, Nishimoto M, Hiyama TB, Higo T, Umehara T, Sakamoto K, Ito T, Yokoyama S. Kashiwagi K, et al. Among authors: nishimoto m. Nature. 2016 Mar 3;531(7592):122-5. doi: 10.1038/nature16991. Epub 2016 Feb 22. Nature. 2016. PMID: 26901872
Structural basis for eIF2B inhibition in integrated stress response.
Kashiwagi K, Yokoyama T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Shirouzu M, Ito T. Kashiwagi K, et al. Among authors: nishimoto m. Science. 2019 May 3;364(6439):495-499. doi: 10.1126/science.aaw4104. Science. 2019. PMID: 31048492
HCV IRES Captures an Actively Translating 80S Ribosome.
Yokoyama T, Machida K, Iwasaki W, Shigeta T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Harada Y, Shigematsu H, Shirouzu M, Tadakuma H, Imataka H, Ito T. Yokoyama T, et al. Among authors: nishimoto m. Mol Cell. 2019 Jun 20;74(6):1205-1214.e8. doi: 10.1016/j.molcel.2019.04.022. Epub 2019 May 9. Mol Cell. 2019. PMID: 31080011 Free article.
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D. Zyryanova AF, et al. Among authors: nishimoto m. Mol Cell. 2021 Jan 7;81(1):88-103.e6. doi: 10.1016/j.molcel.2020.10.031. Epub 2020 Nov 20. Mol Cell. 2021. PMID: 33220178 Free PMC article.
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Tanaka M, Yokoyama T, Saito H, Nishimoto M, Tsuda K, Sotta N, Shigematsu H, Shirouzu M, Iwasaki S, Ito T, Fujiwara T. Tanaka M, et al. Among authors: nishimoto m. Nat Chem Biol. 2024 May;20(5):605-614. doi: 10.1038/s41589-023-01513-0. Epub 2024 Jan 24. Nat Chem Biol. 2024. PMID: 38267667
526 results