Nishi T - Search Results

1

Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy.

Salamone A, Terrone G, Di Sapia R, Balosso S, Ravizza T, Beltrame L, Craparotta I, Mannarino L, Cominesi SR, Rizzi M, Pauletti A, Marchini S, Porcu L, Zimmer TS, Aronica E, During M, Abrahams B, Kondo S, Nishi T, Vezzani A. Salamone A, et al. Among authors: nishi t. Neurobiol Dis. 2022 Oct 15;173:105835. doi: 10.1016/j.nbd.2022.105835. Epub 2022 Aug 3. Neurobiol Dis. 2022. PMID: 35932989 Free article.

2

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.

Nishi T, Kondo S, Miyamoto M, Watanabe S, Hasegawa S, Kondo S, Yano J, Watanabe E, Ishi T, Yoshikawa M, Ando HK, Farnaby W, Fujimoto S, Sunahara E, Ohori M, During MJ, Kuroita T, Koike T. Nishi T, et al. Sci Rep. 2020 Oct 13;10(1):17081. doi: 10.1038/s41598-020-74036-6. Sci Rep. 2020. PMID: 33051477 Free PMC article.

3

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).

Koike T, Yoshikawa M, Ando HK, Farnaby W, Nishi T, Watanabe E, Yano J, Miyamoto M, Kondo S, Ishii T, Kuroita T. Koike T, et al. Among authors: nishi t. J Med Chem. 2021 Aug 26;64(16):12228-12244. doi: 10.1021/acs.jmedchem.1c00864. Epub 2021 Aug 13. J Med Chem. 2021. PMID: 34387987 Free article.

4

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice.

Hawkins NA, Jurado M, Thaxton TT, Duarte SE, Barse L, Tatsukawa T, Yamakawa K, Nishi T, Kondo S, Miyamoto M, Abrahams BS, During MJ, Kearney JA. Hawkins NA, et al. Among authors: nishi t. Epilepsia. 2021 Nov;62(11):2845-2857. doi: 10.1111/epi.17062. Epub 2021 Sep 12. Epilepsia. 2021. PMID: 34510432 Free PMC article.

5

Preclinical characterization of [¹⁸F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.

Koike T, Constantinescu CC, Ikeda S, Nishi T, Sunahara E, Miyamoto M, Cole P, Barret O, Alagille D, Papin C, Morley T, Fowles K, Seibyl J, Tamagnan G, Kuroita T. Koike T, et al. Among authors: nishi t. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1148-1156. doi: 10.1007/s00259-021-05565-z. Epub 2021 Oct 15. Eur J Nucl Med Mol Imaging. 2022. PMID: 34651220 Free PMC article.

6

Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.

Kajita Y, Ikeda S, Yoshikawa M, Fukuda H, Watanabe E, Yano J, Lane W, Miyamoto M, Ishii T, Nishi T, Koike T. Kajita Y, et al. Among authors: nishi t. J Med Chem. 2022 Feb 24;65(4):3343-3358. doi: 10.1021/acs.jmedchem.1c01898. Epub 2022 Feb 15. J Med Chem. 2022. PMID: 35166541 Free article.

7

Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.

Nishi T, Metcalf CS, Fujimoto S, Hasegawa S, Miyamoto M, Sunahara E, Watanabe S, Kondo S, White HS. Nishi T, et al. Epilepsia. 2022 Jun;63(6):1580-1590. doi: 10.1111/epi.17232. Epub 2022 Mar 30. Epilepsia. 2022. PMID: 35316533 Free PMC article.

8

Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).

Ikeda S, Kajita Y, Miyamoto M, Matsumiya K, Ishii T, Nishi T, Gay SC, Lane W, Constantinescu CC, Alagille D, Papin C, Tamagnan G, Kuroita T, Koike T. Ikeda S, et al. Among authors: nishi t. Eur J Med Chem. 2022 Oct 5;240:114612. doi: 10.1016/j.ejmech.2022.114612. Epub 2022 Jul 14. Eur J Med Chem. 2022. PMID: 35863274 Free article.

9

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, modifies acute seizure burden and chronic epilepsy-related behavioral deficits following Theiler's virus infection in mice.

Barker-Haliski M, Nishi T, White HS. Barker-Haliski M, et al. Among authors: nishi t. Neuropharmacology. 2023 Jan 1;222:109310. doi: 10.1016/j.neuropharm.2022.109310. Epub 2022 Oct 29. Neuropharmacology. 2023. PMID: 36341806 Free article.

10

Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons.

Wei X, Nishi T, Kondou S, Kimura H, Mody I. Wei X, et al. Among authors: nishi t. Neuropharmacology. 2019 Apr;148:11-20. doi: 10.1016/j.neuropharm.2018.12.028. Epub 2018 Dec 27. Neuropharmacology. 2019. PMID: 30594698 Free PMC article.

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